Planta Med 2003; 69(3): 218-222
DOI: 10.1055/s-2003-38486
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antitumor Activity of Flavones Isolated from Artemisia argyi

Jeong-Min Seo1 , Hyun-Mi Kang1 , Kwang-Hee Son1 , Jong Han Kim1 , Chang Woo Lee1 , Hwan Mook Kim1 , Soo-Ik Chang2 , Byoung-Mog Kwon1
  • 1Korea Research Institute of Bioscience and Biotechnology, Uen-dong, Yoosung-gu, Taejon, Republic of Korea
  • 2Department of Biochemistry, Chungbuk National University, Cheongju, Republic of Korea
Further Information

Publication History

Received: July 15, 2002

Accepted: November 23, 2002

Publication Date:
04 April 2003 (online)

Abstract

The flavones 5,6-dihydroxy-7,3′,4′-trimethoxyflavone (1), 5,6,4′-trihydroxy-7,3′-dimethoxyflavone (2), 5-hydroxy-3′,4′,6,7-tetramethoxyflavone, 5,7,3′-trihydroxy-6,4′,5′-trimethoxyflavone, ladanein, and hispidulin were isolated from the methanolic extracts of the aerial parts of Artemisia argyi and structures of the compounds were elucidated on the basis of their spectral data. These flavones inhibited farnesyl protein transferase with IC50 values of 25 - 200 μg/mL. Compound 2 inhibited proliferation of a couple of tumor cell lines and also inhibited neovascularization in a chick chorioallantoic membrane assay. Without loss of body weight of nude mice, compounds 1 and 2 inhibited growth of a colon tumor (SW620) by 44.6 % and 14.6 %, respectively.

Abbreviations

FPTase:farnesyl protein transferase

CAM:chick embryo chorioallantoic membrane

References

Dr. Byoung-Mog Kwon

Korea Research Institute of Bioscience and Biotechnology

52 Uendong

Yusunggu

Taejon 305-600

Republic of Korea

Phone: +82-42-860-4557

Fax: +82-42-861-2675

Email: kwonbm@kribb.re.kr

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