Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000077.xml
Semin Thromb Hemost 2003; 29(1): 055-060
DOI: 10.1055/s-2003-37939
DOI: 10.1055/s-2003-37939
Orthopedic Outcome Studies and Cost Issues
Further Information
Publication History
Publication Date:
17 March 2003 (online)

ABSTRACT
Standard therapy for years was on-demand therapy. Readers will learn of results of clinical experience in many different countries with a prophylactic approach to therapy as well as ongoing experimental designs to define optimal therapy. The costs of current prophylaxis regimens will be discussed.
KEYWORD
Hemophilia - prophylaxis - factor concentrates - orthopedic outcomes - cost
REFERENCES
- 1 Ahlberg Å. Haemophilia in Sweden. VII: Incidence, treatment and prophylaxis of arthropathy and other musculoskeletal manifestations of haemophilia A and B. Acta Orthop Scand . 1965; 77(Suppl) 7-80
- 2 Aronstam A, Rainsfad S G, Painter M J. Patterns of bleeding in adolescents with severe hemophilia A. BMJ . 1979; 1 469-470
- 3 Allain J P. Dose requirement for replacement therapy in hemophilia A. Thromb Haemost . 1975; 42 825-831
- 4 Brackmann H H, Eickhoff H J, Oldenburg J, Seuser A, Hammerstein U. Controlled study of long-term treatment in children and adolescents at the hemophilia center, Bonn. In: Prophylactic Treatment of Hemophilia A and B: Current and Future Perspectives New York: Science and Medicine 1994: 9-12
- 5 Schramm W. Consensus recommendations for hemophilia treatment in Germany. In: Prophylactic Treatment of Hemophilia A and B: Current and Future Perspectives New York: Science and Medicine 1994: 13-14
- 6 Rosendaal F R. An overview of 20 years of hemophilia treatment in the Netherlands. In: Prophylactic Treatment of Hemophilia A and B: Current and Future Perspectives New York: Science and Medicine 1994: 18-20
- 7 Savidge G F, Majumdar G, Spence K. Experience from St Thomas' Hospital, London. In: Prophylactic Treatment of Hemophilia A and B: Current and Future Perspectives New York: Science and Medicine 1994: 15-17
- 8 Nilsson I M, Berntorp E, Löfqvist T, Pettersson H. Twenty-five years' experience of prophylactic treatment in severe haemophilia A and B. J Intern Med . 1992; 232 25-32
- 9 Kreuz W, Escuriola-Ettinghausen C, Funk M, Schmidt H, Kornhuber B. When should prophylactic treatment in patients with haemophilia A and B start?-The German experience. Haemophilia . 1998; 4 413-417
- 10 Pettersson H, Gilbert M. Musculoskeletal and other haemorrhagic complications. In: Diagnostic Imaging in Hemophilia Berlin: Springer-Verlag 1985: 55-60
- 11 Aledort L M, Haschmeyer R H, Pettersson H, and The Orthopaedic Outcome Study Group. A longitudinal study of orthopaedic outcomes for severe factor-VIII-deficient haemophiliacs. J Intern Med . 1994; 236 391-399
- 12 Ljung R CR. Prophylactic treatment in Sweden-overtreatment or optimal model?. Haemophilia . 1998; 4 409-412
- 13 Bohn R L, Avorn J, Glynn R J. et al . Prophylactic use of factor VIII: an economic evaluation. Thromb Haemost . 1998; 79 932-937
- 14 Björkman S, Carlsson M, Berntorp E, Stenberg P. Pharmacokinetics of factor VIII in humans. Clin Pharmacokinetics . 1992; 22 385-395