Was dieser Beitrag bietet
Das Spektrum und die Effektivität der Therapieoptionen bei Lebermetastasen des kolorektalen
Karzinoms haben sich in den letzten Jahren entscheidend weiterentwickelt. In dieser
Arbeit sollen daher die Therapiekonzepte unter besonderer Berücksichtigung der lokal
abladierenden Therapieverfahren einschließlich ihrer Indikationen und Kontraindikationen
unter Berücksichtigung der Ergebnisse und möglicher Limitationen vorgestellt werden,
um dem klinisch tätigen Radiologen einen Überblick über die verschiedenen Therapiestrategien
zu geben.
Für eilige Leser: s. Zusammenfassung auf S. 70
Literatur
- 1
Berber E, Foroutani A, Garland A M, Rogers S J, Engle K L, Ryan T L, Siperstein A E.
Use of CT Hounsfield unit density to identify ablated tumor after laparoscopic radiofrequency
ablation of hepatic tumors.
Surg Endosc.
2000;
14
799-804
- 2
Bismuth H, Adam R, Levi F, Farabos C, Waechter F, Castaing D, Majno P, Engerran L.
Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant
chemotherapy.
Ann Surg.
1996;
224
509-520
- 3
Bloomston M, Binitie O, Fraiji E, Murr M, Zervos E, Goldin S. et al .
Transcatheter arterial chemoembolization with or without radiofrequency ablation in
the management of patients with advanced hepatic malignancy.
Am Surg.
2002;
68
827-831
- 4
Curley S A, Izzo F, Delrio P, Ellis L M, Granchi J, Vallone P. et al .
Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies:
results in 123 patients.
Ann Surg.
1999;
230
1-8
- 5
Deutsche Krebsgesellschaft und Deutsche Gesellschaft für Chirurgie. Kurzgefasste interdisziplinäre
Leitlinien: Lebermetastasen. Deutsche Krebsgesellschaft und Deutsche Gesellschaft für Chirurgie 2000 10: 182
- 6
Dodd G D , Soulen M C, Kane R A, Livraghi T, Lees W R, Yashimata Y. et al .
Minimally invasive treatment of malignant hepatic tumors: at the threshold of a major
breakthrough.
Radiographics.
2000;
20
9-27
- 7
Giacchetti S, Itzhaki M, Gruia G, Adam R, Zidani R, Kunstlinger F. et al .
Longterm survival of patients with unresectable colorectal cancer liver metastases
following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and
surgery.
Ann Oncol.
1999;
10
663-669
- 8
Giovannini M.
Percutaneous alcohol ablation for liver metastases.
Semin Oncol.
2002;
29
192-195
- 9
Goldberg S N, Gazelle G S, Compton C C, Mueller P R, Tanabe K K.
Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic
correlation.
Cancer.
2000;
88
2452-2463
- 10
Elias D, de Baere T, Smayra T, Ouellet J F, Roche A, Lasser P.
Percutaneous radiofrequency thermoablation as an alternative to surgery for treatment
of liver tumour recurrence after hepatectomy.
Br J Surg.
2002;
89
752-756
- 11
Kemeny N, Huang Y, Cohen A M, Shi W, Conti J A, Brennan M F. et al .
Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from
colorectal cancer.
N Engl J Med.
1999;
341
2039-2048
- 12
Labianca R, Pancera G, Aitini E, Barni S, Beretta A, Beretta G D. et al .
Folinic acid + 5-fluorouracil (5-FU) versus equidose 5-FU in advanced colorectal cancer.
Phase III study of ‘GISCAD’ (Italian Group for the Study of Digestive Tract Cancer).
Ann Oncol.
1991;
2
673-679
- 13
Lorenz M, Müller H H, Schramm H, Gassel H J, Rau H G, Ridwelski K. et al .
Randomized trial of surgery versus surgery followed by adjuvant hepatic arterial infusion
with 5-fluorouracil and folinic acid for liver metastases of colorectal cancer. German
Cooperative on Liver Metastases (Arbeitsgruppe Lebermetastasen).
Ann Surg.
1998;
228
756-762
- 14
Mack M G, Straub R, Eichler K, Engelmann K, Zangos S, Roggan A. et al .
Percutaneous MR imaging-guided laser-induced thermotherapy of hepatic metastases.
Abdom Imaging.
2001;
26
369-374
- 15
Scheele J, Stang R, Altendorf-Hofmann A. et al .
Resection of colorectal liver metastases.
World J Surg.
1995;
19
59-71
- 16
Semelka R C, Helmberger K G.
Contrast agents for MR Imaging of the Liver.
Radiology..
2001;
218
27-38
- 17
Solbiati L, Livraghi T, Goldberg N, Ierace T, Meloni F, Dellanoce M. et al .
Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer:
Long-term results in 117 patients.
Radiology.
2001;
221
159-166
- 18
Valls C, Andia E, Sanchez A, Guma A, Figueras J, Torras J, Serrano T.
Hepatic metastases from colorectal cancer: preoperative detection and assessment of
resectability with helical CT.
Radiology.
2001;
218
55-60
- 19
Vogl T J, Muller P K, Hammerstingl R, Weinhold N, Mack M G, Philipp C, Deimling M.
Malignant liver tumours treated with MRI imaging-guided laser-induced thermotherapy:
Technique and prospective results.
Radiology.
1995;
196
257-265
- 20
Wood T F, Rose D M, Chung M, Allegra D P, Foshag L J, Bilchik A J.
Radiofrequency ablation of 231 unresectable hepatic tumors: indications, limitations,
and complications.
Ann Surg Oncol.
2000;
7
593-600
Korrespondenzadresse
Dr. B. Frericks
Abt. Diagnostische Radiologie
Medizinische Hochschule Hannover
Carl-Neuberg-Str. 1
30625 Hannover
Telefon: +49 511 532-3128
Fax: +49 511 532-3885
eMail: frericks.bernd@mh-hannover.de
