A Case of Diffuse Leptomeningeal Oligodendrogliomatosis Associated with HHV-6 Variant A

T. Stödberg; Y. Deniz; N. Esteitie; B. Jacobsson; M. Mousavi-Jazi; H. Dahl; B. Zweygberg Wirgart; L. Grillner; A. Linde

doi:10.1055/s-2002-36739

Neuropediatrics, Table of Contents

Neuropediatrics 2002; 33(5): 266-270
DOI: 10.1055/s-2002-36739

Short Communication

Georg Thieme Verlag Stuttgart · New York

A Case of Diffuse Leptomeningeal Oligodendrogliomatosis Associated with HHV-6 Variant A

T. Stödberg¹ , Y. Deniz² , N. Esteitie¹ , B. Jacobsson³ , M. Mousavi-Jazi⁴ , H. Dahl⁴ , B. Zweygberg Wirgart⁵ , L. Grillner⁵ , A. Linde⁴

¹Department of Neuropediatrics, Astrid Lindgren Children's Hospital, Karolinska Hospital, Stockholm, Sweden
²Department of Allergy, Asthma and Immunology, Astrid Lindgren Children's Hospital, Karolinska Hospital, Stockholm, Sweden
³Department of Pathology, Karolinska Hospital, Stockholm, Sweden
⁴Swedish Institute for Infectious Disease Control, Microbiology and Tumourbiology Centre, Karolinska Institute, Stockholm, Sweden
⁵Department of Clinical Microbiology, Karolinska Hospital, Stockholm, Sweden

Abstract

We describe a rare case of diffuse leptomeningeal oligodendrogliomatosis associated with the human herpes virus 6 variant A (HHV-6 A). A 2-year-old boy presented with progressive neurological symptoms and hydrocephalus. The patient had a VP shunt placement but did not fully recover. HHV-6 A was detected in both CSF and serum by nested PCR. His symptoms improved repeatedly, but temporarily, on antiviral treatment. An open brain biopsy, ten months after presentation, revealed leptomeningeal tumour as well as the presence of viral DNA in the tumour tissue. The role of HHV-6 A could be that of a reactivated opportunist. However, this case also raises the question whether this neurotropic virus, with malignant transforming properties in vitro, may have a role in pathogenesis in some cases of brain malignancy.

Key words

Human Herpes Virus 6 - PCR - CNS Disease - Hydrocephalus - Neoplasms - Oligodendroglioma

Full Text

References

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Tommy Stödberg

Department of Neuropediatrics, Astrid Lindgren Children's Hospital, Karolinska Hospital

17176 Stockholm

Sweden

Email: tommy.stodberg@ks.se