Studies on Mitochondrial Regulation of the Genome

Summary

Tumours may spontaneously regress. Consequently mammals possess a natural intrinsic regulatory capacity to control the de-differentiation of euploid cells. Bio-immunotherapy was aimed to actively simulate the biomodulating factors leading to such mysterious cures. Big tumours in mammals could re-transform into normal transcription and be cured without apoptosis or lysis following a dietary, balanced biological correction, using amino acids and essential trace element salts. The manifold long-standing aetiological metabolic deficiency, causing different cancer forms, can biologically be compensated. These clinical results were further improved by autologous specific immunotherapy. Non-toxic curative treatment modalities for experimental rat leukaemia were used to elucidate the effect on oncogene transcription. As bio-immunotherapy in rats, horses and in human patients led to a cure, cristae of certain mitochondria gathering around the anaplastic cell-nucleus transformed into electron-dense structures, due to some metal-enzymes concentrating in the matrix and inner mitochondrial membrane. Metals involved were analysed by inductively coupled plasma mass spectrometry. Electron-density was found to be due to an increase in the Fe, Cr, and Ti content in mitochondrial cristae. The specific biological curative activity of these transformed mitochondria could be measured biologically in experimental rat leukaemia. The ensuing reconstitution of leukaemic cells into normal white cell function, without apoptosis or lysis of tumour cells, seem to represent one vector in the inductional control sustaining healthy mammalian organ function. Mitochondria furnish the nucleus with energy but appear also to regulate genes in close interaction with nuclear DNA. The marked analogy in nucleotide sequences between human, monkey and rat chromosomes would indicate that chromosomes actually represent the memory of evolution. Mitochondria with their mtDNA may thus over eons have created the chromosomes, acting as the memory unite in the biological computer of every cell. Mitochondrial and nuclear regulatory co-operation seem also to regulate programmed cell death, thus maintaining healthy organ function and regeneration. Biologically schooled organ-specific mitochondria could probably in the future be used as therapeutic remedies.

Keywords

Mitochondrial function - gene regulation of eukaryotic cells - creation of chromosomal memory - mitochondria effectors of evolution

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