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DOI: 10.1055/s-2002-36554
Karl F. Haug Verlag, in: MVS Medizinverlage Stuttgart GmbH & Co. KG
Studies on Mitochondrial Regulation of the Genome
Publication History
Publication Date:
08 January 2003 (online)

Summary
Tumours may spontaneously regress. Consequently mammals possess a natural intrinsic regulatory capacity to control the de-differentiation of euploid cells. Bio-immunotherapy was aimed to actively simulate the biomodulating factors leading to such mysterious cures. Big tumours in mammals could re-transform into normal transcription and be cured without apoptosis or lysis following a dietary, balanced biological correction, using amino acids and essential trace element salts. The manifold long-standing aetiological metabolic deficiency, causing different cancer forms, can biologically be compensated. These clinical results were further improved by autologous specific immunotherapy. Non-toxic curative treatment modalities for experimental rat leukaemia were used to elucidate the effect on oncogene transcription. As bio-immunotherapy in rats, horses and in human patients led to a cure, cristae of certain mitochondria gathering around the anaplastic cell-nucleus transformed into electron-dense structures, due to some metal-enzymes concentrating in the matrix and inner mitochondrial membrane. Metals involved were analysed by inductively coupled plasma mass spectrometry. Electron-density was found to be due to an increase in the Fe, Cr, and Ti content in mitochondrial cristae. The specific biological curative activity of these transformed mitochondria could be measured biologically in experimental rat leukaemia. The ensuing reconstitution of leukaemic cells into normal white cell function, without apoptosis or lysis of tumour cells, seem to represent one vector in the inductional control sustaining healthy mammalian organ function. Mitochondria furnish the nucleus with energy but appear also to regulate genes in close interaction with nuclear DNA. The marked analogy in nucleotide sequences between human, monkey and rat chromosomes would indicate that chromosomes actually represent the memory of evolution. Mitochondria with their mtDNA may thus over eons have created the chromosomes, acting as the memory unite in the biological computer of every cell. Mitochondrial and nuclear regulatory co-operation seem also to regulate programmed cell death, thus maintaining healthy organ function and regeneration. Biologically schooled organ-specific mitochondria could probably in the future be used as therapeutic remedies.
Keywords
Mitochondrial function - gene regulation of eukaryotic cells - creation of chromosomal memory - mitochondria effectors of evolution
References
- 01
Tallberg Th..
Cancer-immunotherapy by means of polymerized autologous tumour tissue with special
refrence to some patients with pulmonary tumour.
Scand J resp Dis.
(suppl 89)
107
1974;
107-122
Reference Ris Wihthout Link
- 02
Tallberg Th., Tykkä H., Halttunen P., Mahlberg K., Uusitalo R., Uusitalo H., Carlson O., Sandstedt B., Oravisto K., Lehtonen T., Sarna S..
Cancer Immunity. The effect in cancer immunotherapy of polymerised autologous tumour
tissue and supportive measures.
Scand J clin Lab Invest.
39
(suppl. 151)
1979;
Reference Ris Wihthout Link
- 03
Tallberg Th., Tykkä H., Mahlberg K., Halttunen P., Lehtonen T., Kalima T., Sarna S..
Active specific Immunotherapy with supportive measures in the treatment of palliatively
nephrectomized renal adenocarcinoma patients. A thirteen-year follow-up study.
Eur Urol.
11
1985;
233-243
Reference Ris Wihthout Link
- 04
Tallberg Th., Matous B., Tykkä H., Vosmik Fr., Sarna S., Bauer J., Krajsova I., Sundell B..
Malignant melanoma. Effect of postoperative specific immunotherapy and dietary supplementation
on progress and prognosis.
Tumor Diagn u Ther.
12
1991;
139-146
Reference Ris Wihthout Link
- 05
Cole W..
Spontaneous regression of cancer. The metabolic triumph of the host.
Ann NY Acad Sci.
230
1974;
111-115
Reference Ris Wihthout Link
- 06 Tallberg Th., Mahlberg K., Kalima T.. Experimental and clinical studies on cancer immunotherapy. In, Present status of non-toxic concepts in cancer. (Eds.) K-F Klippel, & E Maher Proc Int. Symp. (Karger) Nonweiler/Trier (Basel); April/1986 (1987): 237-263
Reference Ris Wihthout Link
- 07
Avrameas S., Ternynck T..
Biologically active waterinsoluble protein polymers. Their use for isolation of antigens
and antibodies.
J Biol Chem.
242
1967;
1651-1659
Reference Ris Wihthout Link
- 08
Tallberg Th., Kinnunen R. E., Palkama A., Saario E. M. K., Borgström G..
Equine sarcoid successfully treated by bio-immunotherapy.
Dtsch Zschr Onkol (J of Onkol).
26
1994;
34-40
Reference Ris Wihthout Link
- 09
Tallberg Th., Kinnunen R. E., Stenbäck H., Virtanen I., Palkama A..
Bio-immunotherapy of equine sarcoid with special refrence to intracellular histopathological
reactions.
Dtsch Zschr Onkol (J of Oncol).
27
1995;
157-163
Reference Ris Wihthout Link
- 10 Kinnunen R. E., Tallberg Th., Stenbäck H., Sarna S.. Equine Sarcoid Tumour Treated by Autogenous Tumour Vaccine. Anticancer Res. 19 1999; 3367-3374
- 11 Tallberg Th., Stenbäck H., Dabek J., Palkama A.. Complete disapperance of human malignant histiocytoma cells following dietary biotherapy, leading to activation of inductional control mediated by mitochondria. J Aust Coll Nutr & Env Med. 15 (2) 1996; 5-10
- 12 Tallberg Th., Dabek J.. Long Survival Following BioImmunotherapy in Patients Suffering from Metastasised Renal Carcinoma or Malignant Melanoma. Dtsch Zschr Onkol (J of Oncol). 34 2002; 1-8
- 13 Tallberg Th.. Biologish-Immunologische Krebstherapie mit besonderer Beruksichtigung der Rolle von
Mitochondrien, Chalonen, Aminosäuren und Spurelementen. 2. Internationales Wiener Endobiose Symposium. 1-3.November.1996 abstract
Reference Ris Wihthout Link
- 14 Tallberg Th.. Biological cancer treatment based on biomodulation and active specific immunotherapy. Dtsch Zschr Onkol (J of Oncol). 26 1994; 15-26
- 15 Tallberg Th.. Biological Cancer Therapy, Its effect on inductional control, triggered by hormones and mediated by transformed mitochondria. J Aust Coll Nutr & Env Med. 17 (1) 1998; 17-24
- 16 Tykkä H.. Active specific immunotherapy with supportive measures in the treatment of advanced palliatively nephrectomised renal adenocarcinoma. A controlled clinical study. Scand J Urol Nephrol. 1981; (suppl. 63)
- 17 Tallberg Th.. Cancer treatment, based on active nutritional biomodulation, hormonal therapy and specific autologous immunotherapy. J Aust Coll Nutr & Env Med. 15 (1) 1996; 5-23
- 18 Goldman J. M., Melo J. V.. Targeting the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukaemia. (Editorial). New Engl J Med. 344 2001; 1084-1086
- 19 Hallamaa R. E., Lepistö R. L., Tallberg Th.. Treatment of equine summer eczema with an autogenous serum preparation, possibly effected by inductional lipid signals. Dtsch Zschr Onkol (J of Onkol). 33 2001; 57-62
- 20 Tallberg Th.. Mitochondria seem to regulate the genome in the chromosomes they have phylogenetically
created. In, Trends in Biomedicine in Finland XII, ISBN 951- 98328-1-X, ISSN 1236-925X. (Eds.) T Westermarck et al. Nov./2000: 36-38
Reference Ris Wihthout Link
- 21 Scheffler I. E.. Mitochondria. In, Wiley-Liss Publication 1999: 1-300
Reference Ris Wihthout Link
- 22 Anderson K. M., Harris J. E.. Is induction of type 2 programmed death in cancer cells from solid tumors directly related to mitochondrial mass?. Medical Hypotheses. 57 (1) 2001; 87-90
- 23 Tallberg Th.. The Regulatory Function of Mitochondria on Chromosomes in Cancer Cells. Anticancer Res. 21 (3A) 2001; 1536
Correspondence to:
Dr.Med Head Thomas Tallberg
The Institute of Bio-Immunotherapy
Gylden Str. 2 B.
Helsinki 00200 Finland
Phone: 3 58-9-70 03 93 40
Fax: 3 58-9-67 41 17