Carcinoids, Hemangiopericytomas, and Leukemic Infiltrates

Charles B. Whitlow

doi:10.1055/s-2002-36512

Clinics in Colon and Rectal Surgery, Table of Contents

Clin Colon Rectal Surg 2002; 15(4): 295-304
DOI: 10.1055/s-2002-36512

Carcinoids, Hemangiopericytomas, and Leukemic Infiltrates

Charles B. Whitlow

Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, New Orleans, Louisiana

Abstract

ABSTRACT

This article reviews several miscellaneous tumors of the rectum. Carcinoid tumors of the rectum are uncommon tumors arising from cells of the gastrointestinal neuroendocrine system with a wide range of biologic activity. Evaluation of these tumors includes endoscopy, endoscopic ultrasound, magnetic resonance imaging, computed tomography, scintigraphy, and a variety of histologic techniques. Treatment is based on the risk of lymph node and distant metastases. Hemangiopericytomas are rare vascular tumors, which may arise from the pelvis or retroperitoneum. Their evaluation and treatment are discussed. Leukemic infiltration of the colon and rectum is well described in autopsy studies and is being identified with greater frequency endoscopically. Treatment is aimed at the underlying disease process, although radiation has been used in some cases.

KEYWORD

Carcinoid tumors - hemangiopericytoma - leukemic infiltrates

Full Text

References

REFERENCES

1 Oberndorfer S. Karzinoide Tumoren des Dunndarms. Frankfort Z Pathol . 1907; 1 426-432
2 Saltykow S L. Uber die Genese der ``Karzinoiden tumoren'' sowie der ``adenomyoma'' des Darms. Beitr Path Anat . 1912; 54 559-594
3 Gossett A, Mason P. Tumeurs endocrines de l'appendice. Presse Med . 1914; 22 237-240
4 Williams E D, Sandler M. The classification of carcinoid tumors. Lancet . 1963; 238-239
5 Capella C, Heitz P U, Hofler H. Revised classification of neuroendocrine tumors of the lung, pancreas, and gut. Dig . 1994; 55 (suppl 3) S11-S13
6 Godwin J D. Carcinoid tumors: an analysis of 2837 cases. Cancer . 1975; 36 560-569
7 Modlin I M, Sandor A. An analysis of 8305 cases of carcinoid tumors. Cancer . 1997; 79 813-829
8 Quan S HQ, Bader G, Berg J W. Carcinoid tumors of the rectum. Dis Colon Rectum . 1964; 7 197-206
9 Orloff M J. Carcinoid tumors of the rectum. Cancer . 1971; 28 175-180
10 Soga J, Tazawa K. Pathologic analysis of carcinoids. Histologic reevaluation of 62 cases. Cancer . 1971; 28 990-998
11 Thompson G B, van Heerden A J, Martin J K. Carcinoid tumors of the gastrointestinal tract: presentation, management, and prognosis. Surgery . 1985; 98 1054-1062
12 Shebani K O, Souba W W, Finkelstein D M. Prognosis and survival in patients with gastrointestinal tract carcinoid tumors. Ann Surg . 1999; 229 815-823
13 Jetmore A B, Ray J E, Gathright J B. Rectal carcinoids: the most frequent carcinoid tumor. Dis Colon Rectum . 1992; 35 717-725
14 Sauven P, Ridge J A, Quan S H, Sigurdson E R. Anorectal carcinoid tumors. Is aggressive surgery warranted?. Ann Surg . 1990; 211 67-71
15 Burke M, Shepherd N, Mann C V. Carcinoid tumors of the rectum and anus. Br J Surg . 1987; 74 358-361
16 Naunheim K S, Zeitels J, Kaplan E L. Rectal carcinoid tumors-treatment and prognosis. Surgery . 1983; 94 670-676
17 Schindl M, Niederle B, Hafner M. Stage-dependent therapy of rectal carcinoid tumors. World J Surg . 1998; 22 628-634
18 Caldarola V T, Jackman R J, Moertel C G, Dockerty M B. Carcinoid tumors of the rectum. Am J Surg . 1964; 107 844-849
19 Kanter M, Lechago J. Multiple malignant rectal carcinoid tumors with immunocytochemical demonstration of multiple hormonal substances. Cancer . 1987; 60 1782-1786
20 Fitzgerald S D, Meagher A P, Moniz-Pereira P. Carcinoid tumor of the rectum. DNA ploidy is not a prognostic factor. Dis Colon Rectum . 1996; 39 643-648
21 Shirouzu K, Isomoto H, Kakegawa T, Morimatsu M. Treatment of rectal carcinoid tumors. Am J Surg . 1990; 160 262-265
22 Koura A N, Giacco C G, Curley S A. Carcinoid tumors of the rectum. Effect of size, histopathology, and surgical treatment on metastasis free survival. Cancer . 1997; 79 1294-1298
23 Johnson L A, Lavin P, Moertel C G. Carcinoid: the association of histologic growth pattern and survival. Cancer . 1983; 51 882-889
24 Federspeil B H, Burke A P, Sobind L H, Sekitka K M. Rectal and colonic carcinoids. A clinicopathologic study of 84 cases. Cancer . 1990; 65 135-140
25 Taxy J B, Mendelsohn G, Gupta P K. Carcinoid tumors of the rectum. Am J Clinic Pathol . 1980; 74 791-795
26 Matsui K, Iwase T, Kitagawa M. Small, polypoid-appearing carcinoid tumors of the rectum: clinicopathologic study of 16 cases and effectiveness of endoscopic treatment. Am J Gastroenterol . 1993; 88 1949-1953
27 Kloppel G, Heitz P U, Capella C, Solcia E. Pathology and nomenclature of human gastrointestinal neuroendocrine (carcinoid) tumors and related lesion. World J Surg . 1996; 20 132-141
28 Chejfec G, Falkmer S, Askensten U. Neuroendocrine tumors of the gastrointestinal tract. Pathol Res Pract . 1988; 183 143-154
29 Fiocca R, Rindi G, Polak J M. Glucagon, glicentin, proglucagon, PYY, PP and pro-PP-icosapeptide immunoreactivities of rectal carcinoid-tumors and related non-tumor cells. Regul Pept . 1987; 17 9-29
30 Starren E D, Gould V E, Warren W H. Neuroendocrine carcinomas of the colon and rectum: a clinicopathologic evaluation. Surgery . 1988; 104 1080-1089
31 Matsumoto T, Lida M, Suekane H. Endoscopic ultrasonography in rectal carcinoid tumors: contribution to selection of therapy. Gastrointes Endosc . 1991; 37 539-542
32 Fujishima H, Misawa T, Maruoka A. Rectal carcinoid tumor: endoscopic ultrasonographic detection and endocopic removal. Eur J Radiol . 1993; 16 198-200
33 Yoshikane H, Tsukamoto Y, Niwa Y. Carcinoid tumors of the gastrointestinal tract: evaluation with endoscopic ultasonography. Gastrointest Endosc . 1993; 39 375-383
34 Hoegerle S, Altehoefer C, Ghanem N. Whole-body ¹⁸F dopa PET for detection of gastrointestinal carcinoid tumors. Radiology . 2001; 220 373-380
35 Bombardieri E, Maccauro M, de Deckere E. Nuclear medicine imaging of neuroendocrine tumours. Ann Oncol . 2001; 12 (suppl 2) S51-S61
36 Modlin I M, Cornelius E, Lawton G P. Use of an isotopic somatostatin receptor probe to image gut endocrine tumors. Arch Surg . 1995; 130 367-374
37 Moyana T N, Xiang J, Senthilselvan A, Kulaga A. The spectrum of neuroendocrine differentiation among gastrointestinal carcinoids. Importance of histologic grading, MIB-1, p53, and bcl-2 immunoreactivity. Arch Pathol Lab Med . 2000; 124 570-576
38 Genre C F, Roth L M, Reed R J. ``Benign'' rectal carcinoids: a report of two patients with metastases to regional lymph nodes. Am J Clin Pathol . 1971; 56 750-757
39 Tomoda H, Furusawa M, Istsuro H. The policy of surgery for small carcinoid tumors of the rectum. Jpn J Surg . 1989; 19 544-548
40 Imada-Shirakata Y, Sakai M, Kajiyama T. Endoscopic resection of rectal carcinoid tumors using aspiration lumpectomy. Endoscopy . 1996; 28 34-38
41 Ishikawa H, Imanishi K, Otani T. Effectiveness of endoscopic treatment of carcinoid tumors. Endoscopy . 1989; 21 133-135
42 Higaki S, Nishaki M, Mitani N. Effectiveness of local endoscopic resection of rectal carcinoid tumors. Endoscopy . 1997; 29 171-175
43 Iishi H, Tatsuta M, Yano H. More effective endoscopic resection with a two-channel colonoscope for carcinoid tumors of the rectum. Dis Colon Rectum . 1996; 39 1438-1439
44 Oshitani N, Hamasaki N, Sawa Y. Endoscopic resection of carcinoid tumours using an aspiration method with a transparent overcap. J Int Med Res . 2000; 28 241-246
45 Berkelhammer C, Jasper I, Kirvaitis E. ``Band-snare'' resection of small rectal carcinoid tumors. Gastrointest Endosc . 1999; 50 582-585
46 Araki Y, Isomoto H, Shirouzu K. Clinical efficacy of video-assisted gasless transanal endoscopic microsugery (TEM) for rectal carcinoid. Surg Endosc . 2001; 15 402-404
47 Lauffer J M, Zhang T, Modlin I M. Review article: current status of gastrointestinal carcinoids. Aliment Pharmacol Ther . 1999; 13 271-287
48 Horenstein M G, Erlandson R A, Gonzalez-Cueto D M, Rosai J. Presacral carcinoid tumors. Report of three cases and review of the literature. Am J Surg Pathol . 1998; 22 251-255
49 Edelstein P S, Wong D, La Valleur J, Rothenberger D A. Carcinoid tumor: an extremely unusual presacral lesion. Report of a case. Dis Colon Rectum . 1996; 39 938-942
50 Stout A P, Murray M R. Hemangiopericytoma. A vascular tumor featuring Zimmerman's pericytes. Ann Surg . 1942; 116 26-33
51 Enzinger F M, Smith B H. Hemagiopericytoma: an analysis of 106 cases. Hum Pathol . 1976; 7 61-82
52 Spitz F R, Bouvet M, Pisters P WT. Hemangiopericytoma: a 20-year single-institution experience. Ann Surg Oncol . 1998; 5 350-355
53 Backwinkel K D, Diddams J A. Hemangiopericytoma. Report of a case and comprehensive review of the literature. Cancer . 1970; 25 896-901
54 McMaster M J, Soule E H, Ivinns J C. Hemangioperictyoma. A clinicopathologic study and long-term followup of 60 patients. Cancer . 1975; 36 2232-2244
55 Pandey M, Kothar K C, Patel D D. Haemangioperictyoma: current status, diagnosis and management. Eur J Surg Oncol . 1997; 23 282-285
56 Nappi O, Ritter J H, Pettinato G, Wick M R. Hemangiopericytoma: histological pattern or clinicopathologic entity?. Semin Diag Pathol . 1995; 12 221-232
57 Espinosa A, Berga C, Martin-Paredero V. Hemangiopericytoma ischiorectal. Report of a case. J Cardiovasc Surg . 1998; 39 577-581
58 Harrison M J, Leis H T, Johnson B A. Hemangioperi-ctyoma of the sciatic notch presenting as sciatica in a young healthy man: case report. Neurosurgery . 1995; 37 1208-1212
59 Greene R R, Gerbie A B, Gerbie M V, Eckman T R. Hemangiopericytomas of the uterus. Am J Obstet Gynecol . 1970; 106 1020-1031
60 Buscema J, Klein V, Rotmensch J. Uterine hemagiopericytoma. Obstet Gynecol . 1987; 69 104-108
61 Matsuda S, Usui M, Sakurai H. Insulin-like growth factor II-producing intra-abdominal hemangiopericytoma associated with hypoglycemia. J Gastroenterol . 2001; 36 851-855
62 Munoz A K, Berek J S, Fu Y S, Heintz P AM. Pelvic hemagiopericytomas: a report of five cases and literature review. Gynecol Oncol . 1990; 36 380-382
63 Wilbanks G D, Szymanska Z, Miller A W. Pelvic hemangiopericytoma. Report of 4 patients and review of the literature. Am J Obstet Gynecol . 1975; 123 555-569
64 Unal A E, Bayar S, Guler I, Akgul H. Isolated pelvic perfusion for pelvic hemangiopericytoma. J Surg Oncol . 2002; 79 119-122
65 Lorigan J G, David C L, Evans H L, Wallace S. The clinical and radiologic manifestations of hemangioperictyoma. AJR . 1989; 153 345-349
66 Goldman S M, Davidson A J, Neal J. Retroperitoneal and pelvic hemangioperictytomas: clinical, radiologic, and pathologic correlation. Radiology . 1988; 168 13-17
67 Yoo R E, Sunwoo Y C, Markivee C R. Male pelvic hemangiopericytoma on computed tomography. CT J Comp Tomogr . 1986; 10 73-76
68 Kehagias D, Gouliamos A, Vlahos L. MR appearance of pelvic hemangiopericytoma. Eur Radiol . 1999; 9 163-165
69 Middleton L P, Duray P H, Merino M J. The histological spectrum of hemangioperictyoma: application of immunohistochemical analysis including proliferative markers to facilitate diagnosis and predict prognosis. Hum Pathol . 1998; 29 636-640
70 Craven J P, Quigley T M, Bolen J W, Raker E J. Current management and clinical outcome of hemangiopericytomas. Am J Surg . 1992; 163 490-493
71 Smith R B, Machleder H I, Rand R W. Preoperative vascular embolization as adjunct to successful resection of large retroperitoneal haemangioperictyoma. J Urol . 1976; 115 206-208
72 Smullens S N, Scotti D J, Osterhole J L, Weiss A J. Preoperative embolization of retroperitoneal haemangiopericytoma as an aid in their removal. Cancer . 1982; 50 1870-1875
73 Wong P P, Yagoda A. Chemotherapy of malignant hemangioperictyoma. Cancer . 1978; 41 1256-1260
74 Jha N, McNeese M, Barkley H T, Kong J. Does radiotherapy have a role in hemangiopericytoma management?. <~>Report of 14 new cases and a review of the literature. Int J Radiat Oncol Biol Phys . 1987; 13 1399-1402
75 Mira J G, Chu F C, Fortner J G. The role of radiotherapy in the management of malignant hemangiopericytoma. Report of eleven new cases and review of the literature. Cancer . 1977; 39 1254-1259
76 Prolla J C, Kirsner J B. The gastrointestinal lesions and complications of the leukemias. Ann Intern Med . 1964; 61 1084-1103
77 Cornes J S, Jones T G, Fisher G B. Leukemic lesions of the gastrointestinal tract. J Clin Pathol . 1962; 15 305-313
78 Barcos M, Lane W, Gomez G A. An autopsy study of 1206 acute and chronic leukemias (1958 to 1982). Cancer . 1987; 60 827-837
79 Utsunomiya A, Hanada S, Terada A. Adult T-cell leukemia with leukemia cell infiltration into the gastrointestinal tract. Cancer . 1988; 61 824-828
80 Matsushita M, Hajiro K, Okasaki K, Takakuwa H. A minute erosion representing leukemic infiltration in the colon. Endoscopy . 1997; 29 55-56
81 Steinberg J, Brandt L J, Brenner S, Mahadevia P. Acute lymphoblastic leukemia with infiltration of the colon. Am J Gastroenterol . 1988; 83 1002-1004
82 Kuse R, Lueb H. Gastrointestinal involvement in patients with chronic lymphocytic leukemia. Leukemia . 1997; 11 (suppl 2) S50-S51
83 Tucker J, Cachia P G. Gastrointestinal bleeding due to large bowel infiltration by chronic lymphocytic leukemia. Postgrad Med J . 1986; 62 45-46
84 Shim C, Shem J. A case of chronic lymphocytic leukemia-complicated colonic intussusception. Gastro Endosc . 2001; 54 77-78
85 Limberakis A J, Mossler J A, Roberts L. Leukemic infiltration of the colon. Am J Roentgenol . 1978; 131 725-728
86 Kothur R, Marsh F, Posner G, Dosik H. Endoscopic leukemic polyposis. Am J Gastroenterol . 1990; 85 884-886
87 Rabin M S, Bledin A G, Lewis D. Polypoid leukemic infiltration of the large bowel. Am J Roentgenol . 1978; 131 723-724