Flavonoids and Stilbenoids with COX-1 and COX-2 Inhibitory Activity from Dracaena loureiri

Abstract

Fom the stem wood of Dracaena loureiri, a new homoisoflavanone named loureiriol (1) and eight known flavonoid and stilbenoid derivatives, including 5,7-dihydroxy-3-(4-hydroxybenzyl)-4-chromanone (2), 4,4′-dihydroxy-2,6-dimethoxydihydrochalcone (3), 2,4′-dihydroxy-4,6-dimethoxydihydrochalcone (4), 4′-hydroxy-2,4,6-trimethoxydihydrochalcone (5), 4,6,4′-trihydroxy-2-methoxydihydrochalcone (6), 4,3′,5′-trihydroxystilbene (7), 4,3′-dihydroxy-5′-methoxystilbene (8) and 4-hydroxy-3′,5′-dimethoxystilbene (9) were isolated. These compounds were evaluated for their inhibitory activity against the enzymes cyclooxygenase-1 and cyclooxygenase-2. Potent but non-selective activity was found for the stilbenoids 7 - 9 (IC₅₀ 1.29 - 4.92 μM) whereas weak or no activity was observed for the flavonoids 1 - 6.

References

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