Planta Med 2002; 68(8): 748-749
DOI: 10.1055/s-2002-33796
Letter
© Georg Thieme Verlag Stuttgart · New York

Sesquiterpenes with Hepatoprotective Activity from Cnidium monnieri on Tacrine-Induced Cytotoxicity in Hep G2 Cells

Hyuncheol Oh1 , Jung-Sik Kim2 , Eun-Kyoung Song2 , Hyun Cho2 , Do-Hoon Kim3 , Sung-Eun Park2 , Ho-Sub Lee1 , Youn-Chul Kim2
  • 1Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Korea
  • 2MRRC and College of Pharmacy, Wonkwang University, Iksan, Korea
  • 3Korea Food and Drug Administration, Seoul, Korea
Further Information

Publication History

Received: January 17, 2002

Accepted: February 3, 2002

Publication Date:
09 September 2002 (online)

Abstract

Bioassay-guided fractionation of the EtOH extract of Cnidium monnieri (Apiaceae) furnished two hepatoprotective sesquiterpenes, torilin (1) and torilolone (2), together with a new derivative, 1-hydroxytorilin (3). Compounds 1 and 2 showed hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 and 2 were 20.6 ± 1.86 (P < 0.01) and 3.6 ± 0.1 (P < 0.01) μM, respectively. Silybin as a positive control showed an EC50 value of 69.0 ± 3.4 μM.

References

Prof. Dr. Youn-Chul Kim

MRRC and College of Pharmacy

Wonkwang University

Iksan 570-749

South Korea

Email: [email protected]

Fax: +82-63-852-8837