Zusammenfassung
Die Darmpermeabilität wird klassischerweise definiert als das Ausmaß der Durchlässigkeit
der Darmwand. In den letzten Jahren ist die erhöhte Durchlässigkeit für Bakterien
oder Teile von Bakterien mit schweren Krankheitszuständen wie Multiorganversagen in
Verbindung gebracht worden. Dieser Artikel gibt einen Überblick über die Bedeutung
der „klassischen” Permeabilität für Krankheiten des Gastrointestinaltrakts und des
Stoffwechsels und diskutiert die Bedeutung der „Darm-Leber-Achse”, d. h. die Erkrankung
der Leber als Folge einer Darmkrankheit.
Abstract
Cut permeability is classically defined as the degree of diffusion across the gut
wall. In recent years increased permeability for bacteria, or parts of bacteria has
been associated with severe disease states like Multiple Organ Failure. This paper
will review the relevance of “classical” permeability for gastroenterological and
metabolic disease, and discuss the importance of the “gut-liver axis”, signifying
liver disease secondary to intestinal disease.
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Peter B. Soeters,M. D., ph. D.
Academic Hospital Maastricht
P. Debyelaan 26 · P.O. Box 5800
6202 AZ Maastricht · The Netherlands
