Abstract
Type 1 diabetic individuals are known to develop disorders of bone metabolism resulting
in osteopenia. Previous studies have suggested an influence of vitamin D receptor
alleles on bone metabolism and susceptibility for type 1 diabetes mellitus. The present
study was initiated to investigate the distribution of vitamin D receptor alleles
in Caucasian type 1 diabetic patients and their relation to bone turnover parameters.
75 patients were included and compared to 57 healthy controls. Three vitamin D receptor
alleles were examined (BsmI, TaqI and FokI); serum levels of intact osteocalcin, parathyroid
hormone, bone specific alkaline phosphatase, the carboxy terminal extension peptide
of type I procollagen, 25-OH-vitamin D levels, HbA1c and urinary deoxypyridinoline
excretion were measured.
We observed a higher frequency of the TT genotype in diabetic patients, but no difference
in markers of bone turnover between diabetics and non-diabetics in either sex. Bone
turnover was different in men and in women without any association with vitamin D
receptor genotype. No association was found between diabetes duration, age of onset
or metabolic control and bone turnover parameters.
In summary, our results show an association between the TT genotype and diabetes in
Germans, but no difference in bone turnover markers between diabetics and non-diabetics.
Key words
Bone Metabolism - Genetics - Osteopenia - Hormone Receptor - Autoimmune
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