Planta Med 2002; 68(7): 605-609
DOI: 10.1055/s-2002-32901
Original Paper
© Georg Thieme Verlag Stuttgart · New York

Effects of Apigenin on the Serum- and Platelet Derived Growth Factor-BB-Induced Proliferation of Rat Aortic Vascular Smooth Muscle Cells

Tack-Joong Kim1, 2 , Yong-He Zhang3 , Youngsoo Kim1, 2 , Chong-Kil Lee1, 2 , Myung-Koo Lee1, 2 , Jin-Tae Hong1 , Yeo-Pyo Yun1, 2
  • 1College of Pharmacy, Chungbuk National University, Cheongju, Korea
  • 2Research Center for Bioresource and Health, Chungbuk National University, Cheongju, Korea
  • 3Department of Pharmacology, Peking University, The School of Basic Medical Science, Beijing, China
Further Information

Publication History

Received: October 19, 2001

Accepted: February 3, 2002

Publication Date:
22 July 2002 (online)


The inhibitory effects of apigenin on the growth factor-induced proliferative responses, and expression of mitogen-activated protein (MAP) kinase and its downstream c-fos in rat aortic vascular smooth muscle cells (VSMCs) were investigated. Apigenin significantly inhibited both 5 % fetal bovine serum (FBS)- and 50 ng/mL platelet derived growth factor-BB (PDGF-BB)-induced proliferation on primary cultured rat VSMCs in a concentration-dependent manner. In addition, apigenin resulted in a significant inhibition of the FBS-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2) and expression of c-fos mRNA. These results suggest that apigenin inhibits FBS- and PDGF-BB-induced VSMC proliferation, and its activity may be mediated, at least in part, by down regulation of ERK 1/2 and its downstream c-fos mRNA.


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Yeo-Pyo Yun, Ph. D., Professor 

College of Pharmacy

Chungbuk National University

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Republic of Korea


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