Abstract
An enantioselective route to the key intermediate leading to (+)-vernolepin, an antitumor
sesquiterpene, isolated from Vernonia hymenolepis, has been developed starting from the chiral building block having a bicyclo[3.2.1]octane
framework accessible by either enzymatic or catalytic kinetic resolution.
Key words
chiral building block - convex-face stereoselection - (+)-vernolepin precursor - antitumor
sesquiterpene - bicyclo[3.2.1]octenone
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