Planta Med 2002; 68(6): 558-561
DOI: 10.1055/s-2002-32565
Letter
© Georg Thieme Verlag Stuttgart · New York

Aceriphyllic Acid A, A New ACAT Inhibitory Triterpenoid, from Aceriphyllum rossii

Jae-Taek Han1 , Hae-Yeong Kim1 , Young-Doo Park1 , Youn-Hyung Lee1 , Kang-Ro Lee2 , Byoung-Mog Kwon3 , Nam-In Baek1
  • 1Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University, Suwon, Korea
  • 2College of Pharmacy, Sung Kyun Kwan University, Suwon, Korea
  • 3Korea Research Institute of Bioscience & Biotechnology, Taejeon, Korea
Further Information

Publication History

September 20, 2001

February 3, 2002

Publication Date:
01 July 2002 (online)

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Abstract

Two new triterpenoids along with three known ones, 3-oxoolean-12-en-27-oic acid (1), 3α-hydroxyolean-12-en-27-oic acid (2) and 3β-hydroxyolean-12-en-27-oic acid (3), were isolated from Aceriphyllum rossii. The structures of the new compounds were determined to be a 3α,23-dihydroxyolean-12-en-27-oic acid (4) and a 3α,23-dihydroxyolean-12-en-29-oic acid (5) by spectroscopic and chemical methods; they were designated aceriphyllic acids A and B, respectively. Compounds 2, 3 and 4 remarkably inhibited the activity of ACAT.

References

Nam-In Baek

Graduate School of Biotechnology

Kyun Hee University

Seochun-Ri 1

Kiheung-Eup

Yongin-Si

Kyunggi-Do 449-701

Korea

Phone: +82-31-201-2661

Fax: +82-31-204-8116

Email: nibaek@ khu.ac.kr