Preeclampsia Associated With Antiphospholipid and Anti-β2-Glycoprotein-I Antibodies and Postpartum Thrombocytopenia, Cardiac Dysfunction, and Blindness: A Case Report

T. Hamdosch; P. Schmidt-Rhode; H. J. Schäfer; J. Jenning; H. P. Moecke

doi:10.1055/s-2002-32417

Geburtshilfe und Frauenheilkunde, Inhaltsverzeichnis

Geburtshilfe Frauenheilkd 2002; 62(6): 592-595
DOI: 10.1055/s-2002-32417

Fallbericht

Georg Thieme Verlag Stuttgart · New York

Preeclampsia Associated With Antiphospholipid and Anti-β₂-Glycoprotein-I Antibodies and Postpartum Thrombocytopenia, Cardiac Dysfunction, and Blindness: A Case Report

Präeklampsie bei gleichzeitigem Vorliegen von Antiphospholipid- und Anti-β₂-Glykoprotein-I-Antikörpern und postpartaler Thrombozytopenie, Herzfunktionsstörung und Erblindung: Ein FallberichtT. Hamdosch^1,4 , P. Schmidt-Rhode¹ , H. J. Schäfer² , J. Jenning³ , H. P. Moecke³

¹ Department of Obstetrics and Gynecology, Barmbek Hospital, Hamburg
² Department of Pathology and Histopathology, University of Hamburg-Eppendorf
³ Department of Anesthesiology and Intensive Care, Barmbek, Hamburg
⁴ Department of Obstetrics and Gynecology, St. Bonifatius Hospital, Lingen, Germany

Abstract

Zusammenfassung

Fallbericht über eine Patientin mit schwerer Präeklampsie und postpartalen Komplikationen, bei der eine Palette von Autoimmunreaktionen auftrat.

Fallbericht

Eine 27-jährige erstmals Schwangere wurde nach 37-wöchiger Schwangerschaft mit schwerer Präeklampsie eingewiesen. Es wurde ein Kaiserschnitt vorgenommen. Postpartal trat eine gravierende Herzfunktionsstörung auf, sowie eine Thrombozytopenie, Anfälle von Eklampsie und Erblindung. Immunohistochemische Plazenta-Untersuchungen ergaben eine deutliche Ablagerung von terminalem C5b-9 Komplementkomplex im intervillösen Fibrin und intervillösen Ovarialstroma.

Schlussfolgerung

An der Pathogenese der Präeklampsie-Eklampsie kann die Entstehung von C5b-9 Komplementkomplex beteiligt sein.

Abstract

We describe a patient with severe preeclampsia and postpartum complications in whom we investigated a panel of autoimmune reactions.

Case Report

A 27-year-old primigravida was referred at 37 weeks' gestation because of severe preeclampsia. A cesarean section was performed. Postpartum the patient developed severe cardiac dysfunction, thrombocytopenia, eclamptic seizures, and blindness. Immunohistochemical studies of the placenta showed marked deposition of terminal C5b-9 complement complex in intervillous fibrin and in intravillous stroma.

Conclusion

The generation of C5b-9 complement complex may be involved in the pathogenesis of preeclampsia-eclampsia.

Schlüsselwörter

Präeklampsie - Antiphospholipidsyndrom - β₂-GPI-Antikörper - Komplementkomplex C5b-9

Key words

Preeclampsia - Antiphospholipid syndrome - β₂-GPI antibodies - Complement complex C5 b-9

Volltext

Referenzen

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MD DSc Taufik Hamdosch

Abt. Innere Medizin
Kreiskrankenhaus Aurich

Wallinghauser Str. 12

26603 Aurich