Subscribe to RSS
DOI: 10.1055/s-2002-32145
© Johann Ambrosius Barth
50 years of the Institute of Experimental Endocrinology of the Charité (Humboldt University, Berlin) - The way from Aschheim's Laboratory of the 2nd Department of Obstetrics & Gynaecology to a research institute
Publication History
received 21 September 2001
first decision 26 October 2001
accepted 26 October 2001
Publication Date:
10 June 2002 (online)

Summary
The aim of this article is firstly to elucidate the historical roots which preceded the foundation of the first Institute of Experimental Endocrinology in Germany and secondly to illustrate the special development of this Institute with its ups and downs within the context of German history.
Key words:
Early endocrine research in Berlin - Selmar Aschheim - Bernhard Zondek - Walter Hohlweg - Günter Dörner - History of the Institute of Experimental Endocrinology 1951-2001
References
- 1 Aschheim S, Hohlweg W. Über das Verhalten östrogener Wirkstoffe in Bitumen. Dtsch Med Wschr. 1933; 59 12-14
- 2 Aschheim S, Zondek B. Schwangerschaftsdiagnose aus dem Harn (durch Hormonnachweis). Klin Wschr. 1928; 7 8-9
- 3 Butenandt A, Westphal U, Hohlweg W. Über das Hormon des Corpus luteum. Hoppe-Seyler's Z physiol Chemie. 1934; 227 84-98
- 4 Davidowa H, Plagemann A. Decreased inhibition by leptin of hypothalamic arcuate neurons in neonatally overfed young rats. NeuroReport. 2000; 11 2795-2798
- 5 Döcke F, Rohde W, Stahl F, Gerber P, Chaoui R, Gutenschwager I, Schleussner E, Dörner G. Oestrogen-induced desensitization to the negative oestrogen feedback. A mechanism involved in the sex-specific control gonadotrophin secretion during sexual maturation and in adulthood. In: Dörner G, McCann SM, Martini L (eds) Systemic Hormones, Neutransmitters and Brain Development. Monographs in Neural Sciences Karger, Basel-New York 1986 12: 36-44
- 6 Dörner G. Sexualhormonabhängige Gehirndifferenzierung und Sexualität. VEB Gustav Fischer Verlag, Jena und Springer Verlag, Wien-New York 1972: 1-288
- 7 Dörner G. Problems and terminology of functional teratology. Acta biol med germ. 1975; 34 1093-1095
- 8 Dörner G. Hormones and Brain Differentiation. Elsevier Scientifics Publishing Company. Amsterdam-Oxford-New York 1976: 1-276
- 9 Dörner G. Sexual differentiation of the brain. Vitamines and Hormones. 1980; 38 325-381
- 10 Dörner G. Sex-specific gonadotrophin secretion, sexual orientation and gender role behaviour. Exp Clin Endocrinol. 1985; 96 1-6
- 11 Dörner G. Hormon-dependent brain development and preventive medicine. Monogr Neural Sci. 1986; 12 17-27
- 12 Dörner G, Grychtolik H. Zur Entwicklung und Forschungsarbeit des Institut für experimentelle Endokrinologie der Humboldt-Universität. Wiss Z Humboldt-Univ Berlin, Math-Nat R. XIII 705-716 1964;
- 13 Dörner G, Grychtolik H, Hüttenrauch R, Schubert A. Neue Steroide mit hoher myotrop-androgener Wirkungsrelation. Acta biol med germ. 1966; 16 323-325
- 14 Dörner G, Plagemann A. Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life. Horm Metab Res. 1994; 26 213-221
- 15 Dörner G, Plagemann A, Neu A, Rosenbauer J. Gestational diabetes as risk factor for type I childhood-onset diabetes in the offspring. Neuroendocrinol Lett. 2000; 21 355-359
- 16 Dörner G, Rohde W, Stahl F, Krell L, Masius W G. A neuroendocrine predisposition for homosexuality in men. Arch Sex Behav. 1975; 4 1-8
- 17 Dörner G, Staudt J. Perinatal structural sex differentiation of the hypothalamus in rats. Neuroendocrinology. 1969; 5 103-106
- 18 Dörner G, Steindel E, Kohlhoff H, Reiher H, Anders B, Verlohren H J, Hielscher K. Further evidence for preventive therapy of insulin-dependent diabetes mellitus in the offspring by avoiding maternal hyperglycaemia during pregnancy. Exp Clin Endocrinol. 1985; 86 129-140
- 19 Götz F, Dörner G, Malz U, Rohde W, Stahl F, Poppe I, Schulze M, Plagemann A. Short- and long term effects of perinatal interleukin-1β-application in rats. Neuroendocrinology. 1993; 58 344-351
- 20 Götz F, Ohkawa T, Rohde W, Stahl F, Tönjes R, Arai K, Dörner G. Influence of prenatal stress on the fetal neuroendocrine system in rats. II. Partial prevention of acute and long-lasting effects by simultaneous administration of tyrosine. In: Van Loon GR, Kvetnansky R (eds) Stress, Neurochemical and Humoral Mechanisms Gordon & Breach Sciences Publishers, New York 1989: 12-15
- 21 Götz F, Thieme S, Dörner G. Female infertility-effect of perinatal xenoestrogen exposure on reproductive functions in animals and humans. In: Chyczewski L, Niklinski J, Pluygers E (eds.). Endocrine Disrupters and Carcinogenic Risk Assessment, NATO Science Series I, Vol. 340. pp. 202-209 IOS Press, Amsterdam-Berlin-Oxford-Tokyo-Washington 2002
- 22 Hinz G, Ebert A, Goetze G. Der Exodus: Robert Meyer, Selmar Aschheim und Bernhard Zondek. Drei Namen für Tausende. In: Ebert A und Weitzel HK (Hrsg) Die Berliner Gesellschaft für Geburtshilfe und Gynäkologie 1844-1994 de Gruyter, Berlin-New York 1994: 206-242
- 23 Hohlweg W. Veränderungen des Hypophysenvorderlappens und des Ovariums nach Behandlung mit großen Dosen von Follikelhormon. Klin Wochenschr. 1934; 18 92-95
- 24 Hohlweg W, Junkmann K. Die hormonal-nervöse Reglierung des Hypophysenvorderlappens und der Keimdrüsen. Klin Wochenschr. 1932; 11 321-323
- 25 Hohlweg W, Junkmann K. Über die Beziehungen zwischen Hypophysenvorderlappen und Schilddrüse. Pflügers Arch Gesamte Physiol. 1933; 232 148-158
- 26 Inhoffen H H, Hohlweg W. Neue per os wirksame weibliche Keimdrüsenhormon-Derivate: 17-Aethinyl-Östradiol und Pregnen-in-on-ol-17. Naturwissenschaften. 1938; 26 96
- 27 Kaufmann C. Umwandlung der Uterusschleimhaut einer kastrierten Frau aus dem atrophischen Stadium in das der sekretorischen Funktion durch Ovarialhormone. Zbl Gynäkol. 1932; 56 2058-2061
- 28 Plagemann A, Harder T, Kohlhoff R, Rohde W, Dörner G. Overweight and obesity in infants of mothers with long-term insulin-dependent diabetes or gestational diabetes. Int J Obesity. 1997a; 21 451-456
- 29 Plagemann A, Harder T, Kohlhoff R, Rohde W, Dörner G. Glucose tolerance and insulin secretion in infants of mothers with pregestational insulin-dependent diabetes mellitus or gestational diabetes. Diabetologia. 1997b; 40 1094-1100
- 30 Plagemann A, Harder T, Melchior K, Rake A, Rohde W, Dörner G. Elevation of hypothalamic neuropeptide Y-neurons in adult offspring of diabetic mother rats. NeuroReport. 1999a; 10 3211-3216
- 31 Plagemann A, Harder T, Rake A, Voits M, Fink H, Rohde W, Dörner G. Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome X-like alterations in adulthood of neonatally overfed rats. Brain Res. 1999b; 836 146-155
- 32 Plagemann A, Harder T, Rake A, Waas T, Melchior K, Ziska T, Rohde W, Dörner G. Observations on the orexigenic hypothalamic neuropeptide Y-systems in neonatally overfed weanling rats. J Neuroendocrinol. 1999c; 11 541-546
- 33 Rohde W, Ohkawa T, Götz F, Stahl F, Tönjes R, Arai K, Dörner G. Influence of perinatal stress on the fetal neuroendocrine system in rats. I. Acute effect on hypothalamic neurotransmitters, neurohormones, opioids and systemic hormone levels. In: Van Loon GR, Kvetnansky R (eds) Stress, Neurochemical and Humoral Mechanisms Gordon & Breach Sciences Publishers, New York 1989: 40-44
- 34 Stahl F, Dörner G. Spezifitätserhöhung einer einfachen fluorometrischen Bestimmungsmethode für freies Cortisol und Corticosteron. Acta biol med germ. 1964; 13 424-432
- 35 Zondek B, Aschheim S. Das Hormon des Hypophysenvorderlappens. I. Testobjekt zum Nachweis des Hormons. Klin Wochenschr. 1927; 6 248-252
- 36 Zondek B, Aschheim S. Das Hormon des Hypophysenvorderlappens. II. Darstellung, chemische Eigenschaften, biologische Wirkungen. Klin Wochenschr. 1928; 7 839-835
1 Most recently named as Aschheim-Zondek-Haus
Prof. Dr. Wolfgang Rohde
Institute of Experimental Endocrinology
Humboldt University Medical School (Charité)
Schumannstr. 20/21
10098 Berlin
Phone: + 49-30-450524061
Fax: + 49-30-450524922
Email: wolfgang.rohde@charite.de