Cytotoxic Terpenoid and Immunosuppressive Phenolic Glycosides from the Root Bark of Dictamnus dasycarpus

Abstract

Five new compounds, two degraded terpene glycosides, dasycarpusides A and B (1, 2), and three phenolic glycosides, 2-methoxy-4-hydroxymethylphenol 1-O-α-rhamnopyranosyl-(1″→6′)-β-glucopyranoside (3), 2-methoxy-4-acetylphenol 1-O-α-rhamnopyranosyl-(1″→6′)-β-glucopyranoside (4), and 2-methoxy-4-(8-hydroxyethyl)-phenol 1-O-α-rhamnopyranosyl-(1″→6′)-β-glucopyranoside (5), were isolated from the water-soluble constituents of the root bark of Dictamnus dasycarpus Turcz. (Rutaceae). Their structures were elucidated by spectroscopic analysis and chemical evidence. Moreover, it was found that dasycarpuside A (1) showed weak cytotoxic activity against A-549 (human lung adenocarcinoma) cell line, while 4 and 5 showed more remarkable activity of inhibiting the proliferation of T-cells in vitro.

Key words

Dictamnus dasycarpus - Rutaceae - dasycarpusides A and B - phenolic glycosides - cytotoxic activity - immunosuppressive activity

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