Planta Med 2002; 68(5): 463-464
DOI: 10.1055/s-2002-32075
Letter
© Georg Thieme Verlag Stuttgart · New York

Furocoumarins from Angelica dahurica with Hepatoprotective Activity on Tacrine-Induced Cytotoxicity in Hep G2 Cells

Hyuncheol Oh1 , Ho-Sub Lee1 , Taewan Kim2 , Kyu-Yun Chai2 , Hun-Taeg Chung2 , Tae-Oh Kwon2 , Jung-Yang Jun3 , Ok-Sam Jeong3 , Youn-Chul Kim3 , Young-Gab Yun2
  • 1Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Korea
  • 2Medicinal Resources Research Center, Wonkwang University, Iksan, Chonbuk, Korea
  • 3MRRC and College of Pharmacy, Wonkwang University, Iksan, Chonbuk, Korea
Further Information

Publication History

July 27, 2001

November 10, 2001

Publication Date:
07 June 2002 (online)

Abstract

Fractionation of the MeOH extract of Angelica dahurica Benth et Hook resulted in the isolation of six furocoumarins, imperatorin (1), isoimperatorin (2), (±)-byakangelicol (3), (+)-oxypeucedanin (4), (+)-byakangelicin (5), and (+)-aviprin (6). Among these, compounds 1 and 5 exhibited strong hepatoprotective activities, displaying EC50 values of 36.6 ± 0.98 and 47.9 ± 4.6 μM, respectively. Compounds 3 and 4 showed moderate activities with EC50 values of 112.7 ± 5.35 and 286.7 ± 6.36 μM, respectively. Silybin as a positive control showed the EC50 value with 69.0 ± 3.4 μM. Comparison of hepatoprotective activities for six furocoumarins 1 - 6 suggested that oxy-substitution at the C-9 position increased the hepatoprotective activity.

References

Prof. Young-Gab Yun

Medicinal Resources Research Center

Wonkwang University

Iksan, Chonbuk 570-749, Korea

Email: [email protected]

Fax: +82-63-856-5056