Endoscopy 2002; 34(6): 499-502
DOI: 10.1055/s-2002-32008
Case Report
© Georg Thieme Verlag Stuttgart · New York

A Case of Hyperplastic Polyposis of the Colon with Adenocarcinomas in Hyperplastic Polyps after Long-Term Follow-Up

N.  Koide 1 , Y.  Saito 1 , T.  Fujii 1 , H.  Kondo 1 , D.  Saito 1 , T.  Shimoda 2
  • 1Deptartment of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
  • 2Clinical Laboratory Department, National Cancer Center Hospital, Tokyo, Japan
Further Information

Publication History

30 August 2001

19 December 2001

Publication Date:
04 June 2002 (online)

A 66-year-old woman had been receiving follow-up since 1990 for hyperplastic polyposis, which remained unchanged endoscopically and radiologically. In 1999, a small (28 × 22 mm) superficial adenocarcinoma was detected in the ascending colon. Histologically, this was a hyperplastic polyp containing a well-differentiated adenocarcinoma invading into the submucosa. A review of the English and Japanese literature identified 32 cases of “hyperplastic polyposis.” In about half of the 32 cases, an adenocarcinoma was also found amongst the hyperplastic polyps. Half of the adenocarcinomas were located in the right colon. Although hyperplastic polyposis is uncommon, it warrants regular surveillance, as it appears to be associated with an increased risk of colorectal cancer.


N. Koide, M.D.

Dept. of Endoscopy · National Cancer Center Hospital

5-1-1 Tsukiji · Chuo-ku · Tokyo 104-0045 · Japan

Fax: + 81-3-3542-3815

Email: nkoide@ncc.go.jp