The human cytomegalovirus (HCMV) protease catalyzes the maturational process of the
herpes virus assembly protein and plays a key role during the manufacture of viral
capsid, and so is an attractive target for potential anti-herpes-virus agents with
novel structures and new mechanisms. In this work, a peptidomimetic skeleton was designed
and a chemical library containing 32 compounds with different substitutions on the
skeleton was prepared by the oxidation of a precursor library, which was constructed
from four types of building blocks: 4 carboxylic acids, 2 amines, 2 aldehydes and
2 isocyanides, based on multicomponent condensation following liquid phase strategies.
The syntheses of the key building block isocyanides are presented.
combinatorial chemistry - condensation - antiviral agents - isocyanides - peptides
