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Aktuelle Neurologie 2002; 29: 28-29
DOI: 10.1055/s-2002-27793
Übersicht
© Georg Thieme Verlag Stuttgart · New York

Störungen reproduktiver Funktionen durch Antiepileptika

Disorders of Reproductive Function Induced by Antiepileptic DrugsJürgen  Bauer1
  • 1Klinik und Poliklinik für Epileptologie, Universitätsklinikum Bonn
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Publication History

Publication Date:
03 May 2002 (online)

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Einleitung

Die Geburtenrate ist bei Frauen mit Epilepsie im Alter zwischen 24 und 40 Jahren signifikant gemindert [1]. Zu den möglichen Störungen der Fertilität tragen unmittelbare (epileptische Aktivität, Antiepileptika) und mittelbare (Stress, Depression) Faktoren der Erkrankung Epilepsie bei.

Literatur

  • 1 Wallace H, Shorvon S, Tallis R. Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2,052,922 and age-specific fertility rates of women with epilepsy.  Lancet. 1998;  352 1970-1973
    CrossrefPubMedGoogle Scholar
  • 2 Herzog A G. A relationship between particular reproductive endocrine disorders and the laterality of epileptiform discharges in women with epilepsy.  Neurology. 1993;  43 1907-1910
    PubMedGoogle Scholar
  • 3 Cummings L N, Giudice L, Morrell M J. Ovulatory function in epilepsy.  Epilepsia. 1995;  36 355-359
    PubMedGoogle Scholar
  • 4 Bauer J, Burr W, Elger C E. Seizure occurrence during ovulatory and anovulatory cycles in patients with temporal lobe epilepsy: a prospective study.  Eur J Neurol. 1998;  5 83-88
    CrossrefPubMedGoogle Scholar
  • 5 Bauer J, Stoffel-Wagner B, Flügel D. et al . Serum androgens return to normal following temporal lobe epilepsy surgery in men.  Neurology. 2000;  55 820-824
    PubMedGoogle Scholar
  • 6 Bauer J, Stoffel-Wagner B, Flügel D. et al . The impact of epilepsy surgery on sex serum hormones and menstrual cycles in female patients.  Seizure. 2000;  9 389-393
    CrossrefPubMedGoogle Scholar
  • 7 Bauer J, Jarre A, Klingmüller D, Elger C E. Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women.  Epilepsy Res. 2000;  41 163-167
    CrossrefPubMedGoogle Scholar
  • 8 Genton P, Bauer J, Duncan S. et al . On the association between valproate and polycystic ovary syndrome.  Epilepsia. 2001;  42 295-304
    CrossrefPubMedGoogle Scholar
  • 9 Fody E P, Walker E M. Effects of drugs on the male and female reproductive systems.  Ann Clin Lab Sci. 1985;  15 451-458
    PubMedGoogle Scholar
  • 10 Bauer J. Epilepsy therapy: issues in women and men.  Curr Opin Neurol . 2001;  14 199-202
    CrossrefPubMedGoogle Scholar
  • 11 Herzog A G, Levesque L A. Testosterone, free testosterone, non-sex hormone-binding globulin-bound testosterone, and free androgen index: which testosterone measurement is most relevant to reproductive and sexual function in men with epilepsy.  Arch Neurol. 1992;  49 133-135
    PubMedGoogle Scholar
  • 12 Stoffel-Wagner B, Bauer J, Flügel D. et al . Serum sex-hormones are altered in patients with chronic focal epilepsies treated with anticonvulsant drugs.  Epilepsia. 1998;  39 1164-1173
    PubMedGoogle Scholar
  • 13 Rättyä J, Turkkä J, Pakarinen A J. et al . Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy.  Neurology. 2001;  56 31-36
    CrossrefPubMedGoogle Scholar
  • 14 McCaul K D, Gladue B A, Joppa M. Winning, losing, mood, and testosterone.  Horm Behav. 1992;  26 486-504
    CrossrefPubMedGoogle Scholar
  • 15 Herzog A G, Klein P, Jacobs A R. Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism.  Neurology. 1998;  50 782-784
    PubMedGoogle Scholar

Prof. Dr. Jürgen Bauer

Universitätsklinik für Epileptologie

Sigmund-Freud-Straße 25

53105 Bonn

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