Abstract
From an ethanol extract of the stems of Burasaïa madagascarensis Thouars (Menispermaceae) were isolated N-acetylnornuciferine and two clerodane-type diterpenes, one of them, epicordatine,
being new. The structures were established by the interpretation of the spectral data.
All the described compounds exhibited weak antimalarial activity.
References
- 1
Rasoanaivo P, Ratsimamanga-Urverg S, Rakoto-Ratsimamanga A, Raharisololalao A.
Constituants chimiques de trois espèces de Burasaïa (Ménispermacées) endémiques de Madagascar.
Biochemical Systematics and Ecology.
1991;
19
433-7
- 2 Resplandy A. Sur les alcaloïdes du Burasaïa madagascariensis. Comptes Rendus Académie des Sciences (Paris), 1958; 247 : 2428 - 31; Thèse de Doctorat
ès Sciences. Université de Paris Paris; 1958
- 3
Hufford C D.
Four new N-acetylnoraporphine alkaloids from Liriodendron tulipifera
.
Phytochemistry.
1976;
15
1169-71
- 4
Martin M T, Frappier F, Rasoanaivo P, Randrianarivelojosia M.
Spectral assignment of strychnobrasiline.
Magnetic Resonance Chemistry.
1996;
34
489-91
- 5
Achenbach H, Hemrich H.
Clerodane-type diterpenes and other constituents of Penianthus zenkeri
.
Phytochemistry.
1991;
30
1957-62
- 6
Dadoun H, Muller A H, Cesario M, Guilhem J, Pascard C.
Cordatin, a new diterpene from Apasristhmium cordatum
.
Phytochemistry.
1987;
26
2108-10
- 7 Overton K H, Weir N G, Wylie A. The stereochemistry of the Colombo root bitter principles. Journal
of the Chemical Society 1966: 1482-90
- 8
Tuntiwachwuttikul P, Boonrasri N, Bremner J B, Taylor W C.
Rearranged clerodane diterpenes from Tinospora baenzigeri
.
Phytochemistry.
1999;
52
1335-40
- 9
Wright C W, Phillipson J D.
Natural products and the development of selective antiprotozoal drugs.
Phytotherapy Research.
1990;
4
127-39
- 10
Frappier F, Jossang A, Soudon J, Calvo F, Rasoanaivo P, Ratsimamanga-Urverg S, Saez J,
Schrével J, Grellier P.
Bisbenzylisoquinoleines as modulators of chloroquine resistance in Plasmodium falciparum and multidrug resistance in tumor cells.
Antimicrobial Agents Chemotherapy.
1996;
40
1476-81
Dr. François Frappier
Laboratoire de Chimie des Substances Naturelles, ESA 8041 CNRS
Muséum National d"Histoire Naturelle
63 rue Buffon, 75231 Paris Cedex 05, France
eMail: frappier@mnhn.fr.
Fax: +33-01-40-79-31-35