Planta Med 2002; 68(4): 361-363
DOI: 10.1055/s-2002-26746
Letter
© Georg Thieme Verlag Stuttgart · New York

Antibacterial Diterpenoids from Fabiana densa var. ramulosa

Silvia Erazo1 , Mercedes Zaldívar2 , Carla Delporte1 , Nadine Backhouse1 , Paola Tapia2 , Eliana Belmonte3 , Franco Delle Monarche4 , Rosa Negrete1
  • 1Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile
  • 2Department of Biochemistry and Molecular Biology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile
  • 3Department of Archeology and Museumlogy, Faculty of Social, Administrative and Economical Science, University of Tarapaca, Arica, Chile
  • 4Centro Chimica dei Recettori, C.N.R., Roma, Italy
Further Information

Publication History

June 13, 2001

September 22, 2001

Publication Date:
02 May 2002 (online)

Abstract

A biologically monitored fractionation of the resinous exudate of Fabiana densa Remy var. ramulosa Wedd. led to the isolation of the two new diterpenes: ent-beyer-15-en-18-O-succinate and ent-beyer-15-en-18-O-oxalate as the unique compounds responsible for the observed antibacterial activity of this extract. Their structures were determined by 1D and 2D NMR spectroscopy.

References

Silvia Erazo

Department of Pharmacological and Toxicological Chemistry

Faculty of Chemical and Pharmaceutical Sciences

University of Chile

P.O. Box 233, Santiago-1

Chile

Fax: +56-2-2227900

Email: [email protected]