Abstract
This study aimed to evaluate a simplified minimal model protocol for measuring insulin
sensitivity in mild and severe type 2 diabetes, considering that changes in serum
insulin during an insulin-modified intravenous glucose tolerance test almost only
reflect the insulin injection. Two groups of diabetics treated with high doses of
antidiabetic agents were recruited. Mean insulin responses were calculated in group
1 (n = 30). In group 2 (n = 38), we compared insulin sensitivity (SI) obtained with
reference protocol with SI calculated by a minimal model procedure including the theoretical
average insulin profile determined in group 1, and with Homeostasis Model Assessment
(HOMA-R). Additionally, the cost of each procedure was calculated. SI measured by
the reference method strongly correlated with SI determined by the simplified protocol
(r = 0.966, p < 0.0001), while no correlation was found with HOMA-R (r = - 0.349,
NS). Reduction of cost for HOMA-R and simplified minimal model procedure were - 92
and - 81 %, respectively. This simplified and relative inexpensive protocol, using
minimal model procedure without insulin measurement, accurately measures SI regardless
of β-cell defect degree. This approach could be of interest when limits of validity
of simple indexes are reached.
Key words
Insulin Resistance - Type 2 Diabetes - Minimal Model - Basal Indexes - HOMA
in vivo insulin action in humans: comparison of the insulin clamp and the minimal model techniques.
Horm Metab Res.
1985;
17
406-409
a-perez_martin@chu-montpellier.fr
