Synlett 2001; 2001(1): 0126-0128
DOI: 10.1055/s-2001-9697
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Convenient Synthesis of a New Class of N2SO or N2S2 Tetradentate Ligands Suitable for Nuclear Medicine Applications

Loic Fourteau* , Eric Benoist, Michèle Dartiguenave
  • *Laboratoire de Chimie Inorganique, Université Paul Sabatier, Bat. IIR1, 118, route de Narbonne, 31062 Toulouse, France; Fax (33)-5-61-55-61-18; E-mail:
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31. Dezember 2001 (online)

In our search for a 99mTc labelled brain perfusion imaging agent, six new tetradentate acyclic ligands have been synthesised in good yield, through easy and fast syntheses. These compounds possess an aromatic ring bridging a nitrogen and an oxygen or a sulfur and contain two amides (1a, 1b) or an amine and an amide functionalities (2a-2d), which make them good candidates for radiopharmaceuticals.