Exp Clin Endocrinol Diabetes 2001; 109(8): 402-405
DOI: 10.1055/s-2001-18993

© Johann Ambrosius Barth

No evidence for involvement of alleles of the 825-C/T polymorphism of the G-protein subunit β3 in body weight regulation

A. Hinney 1 , F. Geller 2 , T. Neupert 1 , C. Sommerlad 1 , G. Gerber 1 , T. Görg 2 , W. Siegfried 3 , H. Goldschmidt 4 , H. Remschmidt 1 , A. Ziegler 2 , J. Hebebrand 1
  • 1 Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps-University of Marburg, Germany
  • 2 Institute of Medical Biometry and Epidemiology, Philipps-University of Marburg, Germany
  • 3 Obesity Treatment Centre Insula, Berchtesgaden, Germany
  • 4 Spessart Klinik, Bad Orb, Germany
Further Information

Publication History

Publication Date:
13 December 2001 (online)


The 825-C/T polymorphism of the β3 subunit of the heterotrimeric G protein gene (GNB3) has been shown to be associated with essential hypertension in humans. Recently, it was also reported that the 825-T allele has a higher frequency in obese than non-obese hypertensives suggesting that the primary effect of this allele is on body weight. The association to hypertension might merely be a secondary effect of the higher weight of the respective allele carriers. - To investigate an involvement of the 825-T allele in body weight regulation in young individuals, we evaluated allele frequencies in 440 extremely obese children and adolescents (82.9% had a body mass index [BMI] ≥ 99th percentile), 51 obese students (BMI ≥ 90th percentile), 110 normal weight students (BMI between 40th and 60th percentile) and 144 underweight students (BMI ≤ 15th percentile). The study groups were genotyped by polymerase chain reaction with subsequent restriction fragment length polymorphism analysis (PCR-RFLP). The one-sided Yates-corrected χ 2-test and the Cochran-Armitage trend test for association were performed. Tests for association were negative. The 825-T allele frequencies were similar in the four study groups belonging to different weight ranges (extreme early onset obesity: 0.29; obesity: 0.28; normal weight: 0.35; underweight: 0.32). Similarly, genotype frequencies did not differ between the groups. We concluded that the 825-T allele of the GNB3 does not play a major role in weight regulation in German children, adolescents and young adults.


Dr. Anke Hinney

Clinical Research Group

Department of Child and Adolescent Psychiatry

Schützenstr. 49

D-35039 Marburg


Phone: + 49-64 21-2 86 53 61

Fax: + 49-64 21-2 86 30 56

Email: Anke.Hinney@med.uni-marburg.de