Klinische Neurophysiologie 2001; 32(4): 232-236
DOI: 10.1055/s-2001-18956
Originalia
© Georg Thieme Verlag Stuttgart · New York

Seltene und neuere Indikationen für Botulinumtoxin

New Indications for Botulinum ToxinW.  H.  Jost1 , M.  Naumann2
  • 1Neurologie der Deutschen Klinik für Diagnostik, Wiesbaden
  • 2Neurologische Universitätsklinik, Würzburg
Further Information

Publication History

Publication Date:
11 December 2001 (online)

Zusammenfassung

Das Spektrum therapeutischer Möglichkeiten mit Botulinumtoxin weitet sich zunehmend aus. Es umfasst neben der Behandlung dystoner Störungen, der Spastik und der Schmerzbehandlung, mittlerweile auch viele nicht neurologische Indikationen. Hier sind u. a. dermatologische (Hyperhidrosis), gastroenterologische (Achalasie), proktologische (Analfissur) und urologische (Detrusor-Sphinkter-Dyssynergie) Erkrankungen und Symptome zu nennen. Einige Indikationen werden sehr häufig und an vielen Zentren behandelt, andere sind auf Einzelfälle und wenige Anwender beschränkt. Die vorliegende Arbeit soll eine orientierende Übersicht geben.

Abstract

The range of therapeutic applications for botulinum toxin is rapidly increasing. It encompasses the treatment of dystonic disorders, spasticity, headache and also quite a few non-neurologic disorders. They include various medical spheres such as dermatology (hyperhidrosis), gastroenterology (achalasia), proctology (anal fissure) and urology (detrusor-sphincter-dyssynergia). The use of botulinum toxin has become widespread for some of these entities, in others only few individual cases have been treated and its use is restricted to a few centers. This paper provides an overview of the current therapeutic use of botulinum toxin.

Literatur

  • 1 Annese V, Bassotti G, Coccia G, Dinelli M, D'Onofrio V, Gatto G, Leandro G, Repici A, Testoni P A, Andriulli A. A multicenter randomised study of intrasphincteric botulinum toxin in patients with oesophageal achalasia. GISMA Achalasia study group.  Gut. 2000;  46 597-600
  • 2 Blitzer A, Brin M F, Stewart C F. Botulinum toxin management of spasmodic dysphonia (laryngeal dystonia): a 12 year experience in more than 900 patients.  Laryngoscope. 1998;  108 1435-1441
  • 3 Boroogerdi B, Ferbert A, Schwarz M, Herath H, Noth J. Botulinum toxin treatment of synkinesia and hyperlacrimation after facial palsy.  J Neurol Neurosurg Psychiatry. 1998;  65 111-114
  • 4 Brisinda G, Maria G, Bentivoglio A R, Cassetta E, Gui D, Albanese A. A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.  N Engl J Med. 1999;  341 65-69
  • 5 Cuillière C, Ducrotté P, Zerbib F, Metman E H, de Looze D, Guillemot F, Hudziak H, Lamouliatte H, Grimaud J C, Ropert A, Dapoigny M, Bost R, Lémann M, Bigard M A, Denis P, Auget J L, Galmiche J P, Bruley des Varannes S. Achalasia: outcome of patients treated with intrasphincteric injection of botulinum toxin.  Gut. 1997;  41 87-92
  • 6 Dykstra D D, Sidi A A. Treatment of detrusor-sphincter dyssynergia with botulinum A toxin: a double-blind study.  Arch Phys Med Rehabil. 1990;  71 24-26
  • 7 Dykstra D D, Sida A A, Scott A B, Pagel J M, Goldish G D. Effects of botulinum A toxin on detrusor-sphincter dyssynergia in spinal cord injury patients.  J Urol. 1988;  139 912-922
  • 8 Giess R, Naumann M, Werner E, Riemann R, Beck M, Puls I, Reiners C, Toyka K V. Injections of botulinum toxin into the salivary gland improves sialorrhea in amyotrophic lateral sclerosis.  J Neurol Neurosurg Psychiatry. 2000;  69 121-123
  • 9 Gonzales-Carro P, Perez-Roldan F, Leyaz Huidobro M L, Ruiz Carrillo F, Pedruza Martin C, Saez-Bravo J M. The treatment of anal fissure with botulinum toxin.  Gastroenterol-Hepatol. 1999;  22 163-166
  • 10 Gui D, De Gaetano A, Spada P L, Viggiano A, Cassetta E, Albanese A. Botulinum toxin injected in the gastric wall reduces body weight and food intake in rats.  Aliment Pharmacol Ther. 2000;  14 829-834
  • 11 Gui D, Caessetta E, Anastasio G, Bentivoglio A R, Maria G, Albanese A. Botulinum toxin for chronic anal fissure.  Lancet. 1994;  344 1127-1128 ,  J Pediatr Ophthalmol Strabismus 1998; 35: 9 - 16, 44 - 45
  • 12 Heckmann M, Ceballos-Baumann A, Plewig G. Botulinum toxin A for axillary hyperhidrosis (excessive sweating).  N Engl J Med. 2001;  344 488-493
  • 13 Joo J S, Agachan F, Wolff B, Nagueras B B, Wexner S D. Initial North American experience with botulinum toxin type A for treatment of anismus.  Dis Colon Rectum. 1996;  39 1107-1111
  • 14 Jost W H. One hundred cases of anal fissure treated with botulin toxin: early and long-term results.  Dis Colon Rectum. 1997;  40 1029-1032
  • 15 Jost W H. Treatment of detrusor sphincter dyssynergia with botulinum toxin.  J Neurol. 1999;  246 I/89
  • 16 Jost W H, Schrank B. Chronic anal fissures treated with botulinum toxin injections: a dose-finding study with Dysport®.  Colorectal Dis. 1999;  1 26-28
  • 17 Jost W H, Schrank B. Repeat botulin toxin injections in anal fissure: In patients with relapse and after insufficient effect of the first treatment.  Dig Dis Sci. 1999;  44 1588-1589
  • 18 Jost W. Treatment of drooling in Parkinson's disease with botulinum toxin (letter).  Mov Disord. 1999;  14 1057-1059
  • 19 Jost W H, Müller-Lobeck H. Preoperative use of botulinum toxin in coloproctology: Hypothesis and first results.  Colorectal Dis. 2000;  2 55
  • 20 Kim K S, Kim S S, Yoon J H, Han J W. The effect of botulinum toxin type A injection for intrinsic rhinitis.  J Laryngol Otol. 1998;  112 248-251
  • 21 Laccourreye O, Muscatello L, Gutierrez-Fonseca R, Seckin S, Brasnu D, Bonan B. Severe Frey syndrome after parotidectomy: treatment with botulinum neurotoxin A.  Ann Otolaryngol Chir Cervicofac. 1999;  116 137-142
  • 22 Lundy D S, Lu F L, Cassiano R R, Xue J W. The effect of patient factors on response outcomes to Botox treatment of spasmodic dysphonia.  J Voice. 1998;  12 460-466
  • 23 Maria G, Brisinda G, Bentivoglio A R, Cassetta E, Gui D, Albanese A. Botulinum toxin injections in the internal anal sphincter for the treatment of chronic anal fissures: long-term results after two different dosage regimens.  Ann Surg. 1998;  228 664-669
  • 24 Maria G, Cassetta E, Gui D, Brisinda G, Bentivoglio A R, Albanese A. A comparison of botulinum toxin and saline for the treatment of chronic anal fissure.  N Engl J Med. 1998;  338 217-220
  • 25 Minkes R K, Langer J C. A prospective study of botulinum toxin for internal anal sphincter hypertonicity in children with Hirschsprung's disease.  J Pediatr Surg. 2000;  35 1733-1736
  • 26 Naumann M, Hofmann U, Bergmann I, Hamm H, Toyka K V, Reiners K. Focal hyperhidrosis: Effective treatment with intracutaneous botulinum toxin.  Arch Dermatol. 1998;  134 301-304
  • 27 Naumann M, Bergmann I, Hofmann U, Hamm H, Reiners K. Botulinum toxin for focal hyperhidrosis: technical considerations and improvements of application.  Br J Dermatol. 1998;  139 1123-1124
  • 28 Naumann M, Lowe N. Botulinum toxin type A in the treatment of bilateral primary axillary hyperhidrosis: A randomized, double-blind, placebo-controlled trial.  Br Med J. 2001;  323 596
  • 29 Pasricha P J, Ravich W J, Kalloo A N. Botulinum toxin for achalasia.  Lancet. 1993;  341 244-245
  • 30 Petit H, Wiart L, Gaujard E, Le Breton F, Ferrière J M, Lagueny A, Joseph P A, Barat M. Botulinum A toxin treatment for detrusor-sphincter dyssynergia in spinal cord disease.  Spinal cord. 1998;  36 91-94
  • 31 Schurch B, Hauri D, Rodic B, Curt A, Meyer M, Rossier A B. Botulinum-A toxin as a treatment of detrusor-sphincter dyssynergia: a prospective study in 24 spinal cord injury patients.  J Urol. 1996;  155 1023-1029
  • 32 Schurch B, Stöhrer M, Kramer G, Schmid D M, Gaul G, Hauri D. Botulinum A toxin for treating detrusor hypereflexia in spinal cord injured patients: a new alternative to anticholinergic drugs? Preliminary results.  J Urol. 2000;  164 692-697
  • 33 Tan E K, Jankovic J. Treating severe bruxism with botulinum toxin.  J Am Dent Assoc. 2000;  131 211-216
  • 34 Wehrmann T, Schmitt T H, Arndt A, Lembcke B, Caspary W F, Seifert H. Endoscopic injection of botulinum toxin in patients with recurrent acute pancreatitis due to pancreatic sphincter of oddi dysfunction.  Aliment Pharmacol Ther. 2000;  14 1469-1477
  • 35 Whurr R, Nye C, Lorch M. Meta-analysis of botulinum toxin treatment of spasmodic dysphonia: a review of 22 studies.  Int J Lang Commun Disord. 1998;  33 327-329

Prof. Dr. med. Wolfgang Jost

Leiter des FB Neurologie & Klin. Neurophysiologie · Deutsche Klinik für Diagnostik

Aukammallee 33

65191 Wiesbaden

Email: Jost@botulinumtoxin.de

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