Abstract
Four lignans were isolated from the petrol extract of Myristica argentea mace (Myristicaceae) and their structures were elucidated by means of NMR and mass
spectrometry. Although they have been previously described, NMR data are only available
for threo-austrobailignan-5, which has been isolated only once, and is incomplete. Three of
them, erythro-austrobailignan-6, meso-dihydroguaiaretic acid and nectandrin-B, exert an antiproliferative effect on MCF-7
cells as well as antioxidant activity on the 1,1-diphenyl-2-picrylhydrazyl (DPPH)
radical, but not the threo-austrobailignan-5. Nectandrin-B also possesses anti-17β-hydroxysteroid dehydrogenase and anti-aromatase activities.
Key words
Myristica argentea
- Myristicaceae - lignans - antiproliferative activity - antioxidant activity - anti-17β-HSD
activity - anti-aromatase activity
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Prof. A. J. Chulia
Laboratoire de Pharmacognosie
UPRES EA 1085
UFR de Pharmacie
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