Planta Med 2001; 67(8): 695-699
DOI: 10.1055/s-2001-18344
Original Paper
Clinical studies
© Georg Thieme Verlag Stuttgart · New York

Polysomnographic Evaluation of the Hypnotic Effect of Valeriana edulis Standardized Extract in Patients Suffering from Insomnia

Armando Herrera-Arellano1 , Gustavo Luna-Villegas2 , Ma. Luisa Cuevas-Uriostegui3 , Laura Alvarez4 , Gabriela Vargas-Pineda4 , Alejandro Zamilpa-Alvarez1 , Jaime Tortoriello1,*
  • 1 Centro de Investigación Biomédica del Sur, IMSS., Morelos, México
  • 2 División de Neurociencias, Instituto Mexicano de Psiquiatría, México
  • 3 Unidad de Investigación Médica en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS., México
  • 4 División de Productos Naturales, Centro de Investigación en Ciencias Químicas, Universidad Autónoma del Estado de Morelos, Morelos, México
Further Information

Publication History

October 31, 2000

January 21, 2001

Publication Date:
09 November 2001 (online)


Valeriana edulis ssp. procera, commonly known as ”valeriana mexicana”, is widely used in Mexican traditional medicine for the treatment of insomnia and anxiety. To evaluate the hypnotic effect and safety of 450 mg of Valeriana edulis standardized hydroalcoholic extract in patients with insomnia, a double-blind, cross-over, controlled study was carried out. Valeriana officinalis extract, at the same doses, was used as a positive control. In a sleep laboratory, polysomnographic (PSG) recordings were performed for analyzing the quantity and architecture of sleep as well as evaluating morning sleepiness, memory quotient, and side effects. The experimental procedures were conducted on four consecutive nights of 8 h each. Twenty patients were admitted. Based on the PSG results, V. edulis reduced the number of awaking episodes while both treatments increased the rapid eye movement (REM) sleep; this last parameter was better improved by V. officinalis extract. Other PSG data did not achieve outstanding statistical differences, but the clinical tendency with both treatments was to increase the sleep efficiency index. These Valeriana extracts produced beneficial effects on sleep architecture because they diminished the time of stages 1 and 2 in non-REM sleep while they increased delta sleep. Validated clinical tests showed that both species reduced notoriously the morning sleepiness, that was further improved by V. officinalis extract, and did not affect anterograde memory. In only three cases were slight side effects observed, one due to the experimental extract. Chemical analysis of the hydroalcoholic extract of V. edulis indicated that this extract contains 0.26 % of dihydroisovaltrate as the main valepotriate, and that it does not contain valerenic acid. In general, the results support the hypnotic effect and safety of acute treatment of Valeriana edulis and Valeriana officinalis on patients suffering insomnia.


Dr. Jaime Tortoriello

Centro de Investigación Biomédica del Sur. IMSS

Argentina No. 1



México, C.P. 62790


Fax: (0052) 7 361 21 55