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Synlett 2001; 2001(10): 1567-1568
DOI: 10.1055/s-2001-17446
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Stereoselective Synthesis of (22R)- and (22S)-22-Methyl-1α,25-Dihydroxyvitamin D3

Yagamare Fall* , Carlos Fernandez, Victoria González, Antonio Mouriño
  • *Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Vigo, 36200 Vigo, Ponte vedra, Spain; Fax + 34(986)81 23 82; E-mail: yagamare@uvigo.es
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Publication Date:
27 September 2001 (online)

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An efficient, straightforward method for construction of the side chain of (22R)- and (22S)-22-alkyl-1α,25-dihydroxyvitamin D3 is described. The title compounds were synthesized by Lythgoe's procedure.

1α,25-dihydroxyvitamin D3 - stereoselective synthesis - alkylations - nitriles - 22-substituted analogue

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