Exp Clin Endocrinol Diabetes 2001; 109(6): 307-319
DOI: 10.1055/s-2001-17297

© Johann Ambrosius Barth

Rodent obesity models: An overview

Matthias Tschöp, Mark L. Heiman
  • Endocrine Division, Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, Indiana, USA
Further Information

Publication History

Publication Date:
19 September 2001 (online)


Animal obesity models differ widely in type and extent of obesity. They are either based on environmental factors (eg. high fat diet induced obesity), spontaneous mutants (i.e. ob/ob mice), genetically engineered animals (eg. mice with melanocortin receptor subtype-4 gene disruption (knock-out)) or mechanical intervention (eg. chemical lesion of the ventromedial hypothalamus). This article reviews available rodent models to study obesity and attempts to highlight the greatest utility for each model.


Matthias H. TschoepM.D. 

Endocrine Research

Eli Lilly and Co., LCC, DC 0545

Indianapolis, Indiana 46285


Phone: +317-433-5804

Fax: +317-276-9574

Email: tschoep@gmx.de