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Synlett 2001; 2001(9): 1467-1469
DOI: 10.1055/s-2001-16781
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Synthesis of Structurally Diversified α-Substituted β-Amino Acids and Derivatives via Conjugate Radical Additions and Heck Reactions

Jacques Huck* , Jean-Marie Receveur, Marie-Louise Roumestant, Jean Martinez
  • *Laboratoire des Aminoacides, Peptides et Protéines, UMR CNRS 5810, Universités Montpellier I & II, 2 Place E. Bataillon, 34095 Montpellier Cedex 05, France; Fax (33)04 67 14 48 66; E-mail: recevej@netscape.net
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Publikationsdatum:
28. August 2001 (online)

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An efficient short-step synthesis of α-substituted β-amino, β-hydrazino, β-N-hydroxy esters and β-urethane N-carboxyanhydrides is reported. Structural diversity was easily incorporated in good yields at the α position of the carboxylic group via conjugate radical additions and Heck reactions performed on the conjugated double bond of synthons 3, 8 and 9.

α-substituted β-amino acids - radical addition - Heck reaction - β-UNCAs

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