Exp Clin Endocrinol Diabetes 2001; 109(5): 261-266
DOI: 10.1055/s-2001-16345

© Johann Ambrosius Barth

Expression of arginine vasopressin and vasopressin V1a receptor mRNA in diabetic (db/db) mice

M. Morita, Y. Kita, N. Morikawa, M. Iwami , Y. Notsu
  • Advanced Technological Platform Research Laboratory, Fujisawa Pharmaceutical Co., Ibaraki, Japan
Further Information

Publication History

Publication Date:
31 December 2001 (online)


To assess the involvement of arginine vasopressin (AVP) in genetical diabetic (db/db) mice, we examined the mRNA expression levels of AVP and vasopressin V1a receptors (V1aR) in brain and liver of db/db mice. In 10 week-old db/db mice, a significant elevation in blood sugar levels and plasma osmolality were observed, showing obvious diabetic symptoms. There was a significant increase in brain AVP mRNA levels in db/db mice. The expression level of liver V1aR mRNA in db/db mice was significantly down-regulated, presumably as a consequence of ligand-receptor interaction. This is in contrast to results that show no significant reduction in brain V1aR mRNA levels when comparing db/db and control mice. Thus, it is possible that in the progress of genetic diabetes mellitus, AVP acts in liver than in brain through V1aR.


Dr. Yasuhiro Kita

Molecular Biological Research Laboratory

Fujisawa Pharmaceutical Co., Ltd.

5-2-3 Tokodai, Tsukuba

Ibaraki 300-2698


Phone: +81-298-47-8611

Fax: +81-298-47-1535

Email: Yasahirokia@po.fujisawa.co.jp