Exp Clin Endocrinol Diabetes 2001; Vol. 109(2): 75-82
DOI: 10.1055/s-2001-14826
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© Johann Ambrosius Barth

Intraadrenal mechanisms of DHEA regulation: A hypothesis for adrenopause

S. Alesci, S. R. Bornstein
  • Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health, National Institutes of Health, Bethesda, MD, USA
Further Information

Publication History

Publication Date:
31 December 2001 (online)

Summary:

Dehydroepiandrosterone (DHEA) and its sulfate metabolite DHEAS are the major androgens secreted by the human adrenal gland. The specific control of these hormones remains unclear. While ACTH is a potent stimulator of DHEA secretion, other factors both systemic and local have been involved in adrenal androgen control. Here we review the extra and intra-adrenal regulation of DHEA and propose a hypothetical model for adrenal senescence.

References

Salvatore AlesciMD 

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