Microwave Promoted Synthesis of a Rehabilitated Drug: Thalidomide

Julio A. Seijas; M. Pilar Vázquez-Tato; Cristóbal González-Bande; M. Montserrat Martínez; Beatriz Pacios-López

doi:10.1055/s-2001-14573

SHORTPAPER

Microwave Promoted Synthesis of a Rehabilitated Drug: Thalidomide

Julio A. Seijas*, M. Pilar Vázquez-Tato*, Cristóbal González-Bande, M. Montserrat Martínez, Beatriz Pacios-López
Departamento de Química Orgánica, Facultad de Ciencias. Universidad de Santiago de Compostela, Aptdo. 280, 27080-Lugo, Spain
Fax: +(34)982224904; e-Mail: qoseijas@lugo.usc.es; e-Mail: pilarvt@lugo.usc.es;

Abstract

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Abstract

A new direct synthesis of thalidomide in high yield by microwave irradiation of N-phthaloyl-l-glutamic in the presence of thiourea is described. Thalidomide was also obtained in good yield from l-glutamic acid, phtalic anhydride and thiourea in a one-pot procedure.

Key words

antitumoral agent - antiviral agent - imides - microwave heating - thiourea

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References

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