Planta Med 2001; 67(4): 322-325
DOI: 10.1055/s-2001-14337
Original Paper
© Georg Thieme Verlag Stuttgart · New York

Studies on the Hepatocyte Protective Activity and the Structure-Activity Relationships of Quinic Acid and Caffeic Acid Derivatives from the Flower Buds of Lonicera bournei

Ting Xiang1,*, Quan-Bo Xiong2 , Adnyana I Ketut2 , Yasuhiro Tezuka2 , Takema Nagaoka2 , Li-Jun Wu1,*, Shigetoshi Kadota2
  • 1 Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang, People's Republic of China
  • 2 Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
Further Information

Publication History

June 8, 2000

August 9, 2000

Publication Date:
31 December 2001 (online)


13 quinic acid derivatives along with caffeic acid, methyl caffeate, myo-inositol, bis[5-formylfurfuryl] ether and 6,7-dihydroxycoumarin were isolated from the ethanol extract of the flower buds of Lonicera bournei Hemsl., among which 8 compounds were firstly obtained from this genus. The effects of different solvent soluble fractions of the ethanol extract and the pure compounds on heptocyte death induced by D-galactosamine (D-GalN)/tumor necrosis factor α (TNF-α) were studied, and the structure-activity relationships were also discussed.


Prof. Li-Jun Wu

Department of Natural Medicine

Shenyang Pharmaceutical University

103 Wenhua Road

Shenyang, 110015

People’s Republic of China


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