Planta Med 2001; 67(4): 340-344
DOI: 10.1055/s-2001-14329
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Antiplasmodial and Antioxidant Isofuranonaphthoquinones from the Roots of Bulbine capitata

Merhatibeb Bezabih1 , Berhanu M. Abegaz1,*, Kitiya Dufall2 , Kevin Croft2 , Tina Skinner-Adams3 , Timothy M. E. Davis3
  • 1 Department of Chemistry, University of Botswana, Gaborone, Botswana
  • 2 Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Western Australia
  • 3 Department of Medicine, University of Western Australia, Fremantle Hospital, Western Australia
Further Information

Publication History

April 26, 2000

October 22, 2000

Publication Date:
31 December 2001 (online)


The roots of B. capitata yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-c]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-c]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-c]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10′-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-c]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities.


Professor Berhanu M. Abegaz

Department of Chemistry

University of Botswana

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