Antiplasmodial and Antioxidant Isofuranonaphthoquinones from the Roots of Bulbine capitata

Merhatibeb Bezabih; Berhanu M. Abegaz; Kitiya Dufall; Kevin Croft; Tina Skinner-Adams; Timothy M. E. Davis

doi:10.1055/s-2001-14329

Planta Medica, Table of Contents

Planta Med 2001; 67(4): 340-344
DOI: 10.1055/s-2001-14329

Original Paper

Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Antiplasmodial and Antioxidant Isofuranonaphthoquinones from the Roots of Bulbine capitata

Merhatibeb Bezabih¹ , Berhanu M. Abegaz^1,*, Kitiya Dufall² , Kevin Croft² , Tina Skinner-Adams³ , Timothy M. E. Davis³

¹ Department of Chemistry, University of Botswana, Gaborone, Botswana
² Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Western Australia
³ Department of Medicine, University of Western Australia, Fremantle Hospital, Western Australia

Abstract

The roots of B. capitata yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-c]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-c]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-c]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10′-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-c]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities.

Key words

Bulbine capitata - Asphodelaceae - roots - isofuranonaphthoquinones - antioxidant - antiplasmodial

Full Text

References

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Professor Berhanu M. Abegaz

Department of Chemistry

University of Botswana

P.O. Box 70163

Gaborone

Botswana

Email: abegazb@mopipi.ub.bw

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