Planta Med 2001; 67(4): 340-344
DOI: 10.1055/s-2001-14329
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Antiplasmodial and Antioxidant Isofuranonaphthoquinones from the Roots of Bulbine capitata

Merhatibeb Bezabih1 , Berhanu M. Abegaz1,*, Kitiya Dufall2 , Kevin Croft2 , Tina Skinner-Adams3 , Timothy M. E. Davis3
  • 1 Department of Chemistry, University of Botswana, Gaborone, Botswana
  • 2 Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Western Australia
  • 3 Department of Medicine, University of Western Australia, Fremantle Hospital, Western Australia
Further Information

Publication History

April 26, 2000

October 22, 2000

Publication Date:
31 December 2001 (online)

Abstract

The roots of B. capitata yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-c]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-c]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-c]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10′-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-c]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities.

References

Professor Berhanu M. Abegaz

Department of Chemistry

University of Botswana

P.O. Box 70163

Gaborone

Botswana

Email: abegazb@mopipi.ub.bw

Fax: (267) 355 2836