Planta Med 2001; 67(4): 312-316
DOI: 10.1055/s-2001-14322
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Lignans from the Rhizomes of Coptis japonica Differentially Act as Anti-Inflammatory Principles

Jae Youl Cho1, 2,*, Ae Ra Kim3 , Myung Hwan Park1
  • 1 Department of Immunopharmacology, R & D Center, Daewoong Pharmaceutical Co. Ltd., Sungnam, Korea
  • 2 Department of Immunology, Windeyer Institute of Medical Sciences, University College London Medical School, London, U.K.
  • 3 Department of Pharmacy, College of Pharmacy, Pusan National University, Pusan, Korea
Further Information

Publication History

June 8, 2000

September 10, 2000

Publication Date:
31 December 2001 (online)

Abstract

Coptis japonica Makino (Ranunculaceae) is known to possess several biological activities such as anti-inflammatory effects. In this study, five lignans, isolariciresinol (1), lariciresinol glycoside (2), pinoresinol (3), pinoresinol glycoside (4) and syringaresinol glycoside (5), isolated from the rhizomes of C. japonica were tested to evaluate their in vitro anti-inflammatory effects. Pinoresinol and isolariciresinol showed higher inhibitory effects on TNF-α production, whereas syringaresinol glycoside strongly suppressed lymphocyte proliferation. The results indicate that the lignans may differentially modulate inflammatory cell responses, suggesting that these compounds may participate in anti-inflammatory processes by C. japonica.

References

Jae Youl Cho

Department of Immunology

Windeyer Institute of Medical Sciences

University College London Medical School

46 Cleveland Street

London W1P 6DB

United Kingdom

Email: jae.cho@ucl.ac.uk

Fax: +44 207-679 9357