Planta Med 2001; 67(4): 369-370
DOI: 10.1055/s-2001-14309

© Georg Thieme Verlag Stuttgart · New York

Na+,K+-ATPase Inhibiting Activity of Cardiac Glycosides from Erysimum cheiranthoides

Zhen-Huan Lei1 , Akihiko Kuniyasu2 , Bao-Shin Tai1 , Hitoshi Nakayama2 , Toshihiro Nohara2,*
  • 1 Department of Traditional Chinese Medicine, Heilongjiang Commercial College, Daoli Harbin, China
  • 2 Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Weitere Informationen


May 26, 2000

July 30, 2000

31. Dezember 2001 (online)


We previously reported the isolation of eleven new cardiac glycosides called cheiranthosides I - XI together with two known ones (olitoriside and erysimoside) from the seeds of Erysimum cheiranthoides L. The glycosides were evaluated for their inhibitory activity against Na+,K+-ATPase by comparing with typical cardiac glycosides. Two of them, cheiranthoside III and VIII, showed high inhibiting activity which was equivalent to that of digitoxin. Cheiranthoside XI containing a rhamnopyranosyl digitoxopyranosyl moiety and a carboxyl group showed the lowest activity which was similar to that of the inactive aglycone, strophanthidin. Some characteristics in the structure-activity relationship are also discussed.


Prof. Dr. Toshihiro Nohara

Faculty of Pharmaceutical Sciences

Kumamoto University

Oe-honmachi 5-1

Kumamoto 862-0973


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