Planta Med 2001; 67(4): 369-370
DOI: 10.1055/s-2001-14309
Letter

© Georg Thieme Verlag Stuttgart · New York

Na+,K+-ATPase Inhibiting Activity of Cardiac Glycosides from Erysimum cheiranthoides

Zhen-Huan Lei1 , Akihiko Kuniyasu2 , Bao-Shin Tai1 , Hitoshi Nakayama2 , Toshihiro Nohara2,*
  • 1 Department of Traditional Chinese Medicine, Heilongjiang Commercial College, Daoli Harbin, China
  • 2 Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Further Information

Publication History

May 26, 2000

July 30, 2000

Publication Date:
31 December 2001 (online)

Abstract

We previously reported the isolation of eleven new cardiac glycosides called cheiranthosides I - XI together with two known ones (olitoriside and erysimoside) from the seeds of Erysimum cheiranthoides L. The glycosides were evaluated for their inhibitory activity against Na+,K+-ATPase by comparing with typical cardiac glycosides. Two of them, cheiranthoside III and VIII, showed high inhibiting activity which was equivalent to that of digitoxin. Cheiranthoside XI containing a rhamnopyranosyl digitoxopyranosyl moiety and a carboxyl group showed the lowest activity which was similar to that of the inactive aglycone, strophanthidin. Some characteristics in the structure-activity relationship are also discussed.

References

Prof. Dr. Toshihiro Nohara

Faculty of Pharmaceutical Sciences

Kumamoto University

Oe-honmachi 5-1

Kumamoto 862-0973

Japan

Email: none@gpo.kumamoto-u.ac.jp

Fax: +81-96-362-7799