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Pneumologie 2001; 55(5): 258-264
DOI: 10.1055/s-2001-13949
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© Georg Thieme Verlag Stuttgart · New York

T-Zellrezeptor und Allergie - eine Übersicht

T-Cell Receptor and Allergy - A SurveyV. Liebers, M. Raulf-Heimsoth
  • Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin (BGFA), Institut an der Ruhr-Universität Bochum (Direktor: Priv.-Doz. Dr. T. Brüning), Bochum, Germany
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Publication History

Publication Date:
31 December 2001 (online)

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Einleitung

Das Immunsystem stellt ein hochentwickeltes Abwehrsystem der Wirbeltiere dar, an dem viele verschiedene Zelltypen beteiligt sind. Eine entscheidende Rolle spielen dabei die Lymphozyten mit ihren Antigenrezeptoren. Sie sind für die Spezifität der Reaktionen verantwortlich. B-, T- und NK-Zellen sind die wesentlichen Lymphozytenpopulationen, die unterschieden werden. T-Zellen haben wichtige regulatorische Funktionen. Sie unterstützen als T-Helfer-Zellen bestimmte Immunantworten, z. B. die Immunglobulinproduktion. Die zytotoxischen T-Zellen sind dagegen in direkte Effektorfunktionen involviert, z. B. in die Lyse Virus-infizierter Zellen.

Die Möglichkeit eines Organismus, auf nahezu jedes Fremdantigen zu reagieren, entsteht durch die riesige Auswahl verschiedener T-Zellklone mit ihren Antigenrezeptoren, die für die einzelnen Epitope spezifisch sind.

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Dr Verena Liebers

Berufsgenossenschaftliches Forschungsinstitut
für Arbeitsmedizin (BGFA)
Bereich Allergieforschung

Bürkle-de-la-Camp-Platz 1
44789 Bochum

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