Traceless Synthesis of Urea, Semicarbazide and Carbamate Derivatives Using Bromo-Wang Resin and Bromo-Wang SynPhaseTM Lantern

Chee Wee Phoon; Mui Mui Sim

doi:10.1055/s-2001-13388

Synlett 2001; 2001(5): 0697-0699
DOI: 10.1055/s-2001-13388

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Traceless Synthesis of Urea, Semicarbazide and Carbamate Derivatives Using Bromo-Wang Resin and Bromo-Wang SynPhase^TM Lantern

Chee Wee Phoon^* , Mui Mui Sim

^*Medicinal and Combinatorial Chemistry Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609; Fax (65)7 79 11 17; E-mail: mcbsimmm@imcb.nus.edu.sg

Abstract

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Traceless synthesis of urea, semicarbazide and carbamate derivatives has been carried out successfully on bromo-Wang resin and SynPhase^TM Lantern. The synthetic route is simple and convenient to perform. Most of the products are obtained in high yields and purities after acidic cleavage.

combinatorial chemistry - solid-phase synthesis - traceless cleavage - bromo-Wang resin - bromo-Wang SynPhase^TM Lantern

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