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Exp Clin Endocrinol Diabetes 2001; Vol. 109(1): 32-34
DOI: 10.1055/s-2001-11018
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© Johann Ambrosius Barth

Sodium/iodide symporter (NIS) and cytokines

P.-M. Schumm-Draeger
  • Department of Internal Medicine, University Clinic of Frankfurt/Main, Germany
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Publication History

Publication Date:
31 December 2001 (online)

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Summary:

It has been shown that TSH upregulates rat NIS gene expression in vitro, and this induction can be modulated by cytokines. Analysis of the distribution of rat NIS mRNA ex vivo demonstrated variable levels of NIS transcription in different tissue samples. - IL-1β and IL-6 have been found to decrease NIS mRNA expression in TSH-stimulated FRTL-5-cells. IL-6 has no effect on NIS functional activity, whereas IL-1β suppresses iodide accumulation. The NIS is expressed in thyroid tissue of patients with autoimmune thyroid diseases, and its expression is increased in Graves' disease. With respect to other thyroidal autoantigens such as TPO and Tg, NIS obviously shows a very similar pattern to the well-described antigenic targets and may participate as an autoantigen in these diseases. - Up to now only data of in vitro studies are available which started to evaluate the effects of different cytokines on NIS expression. The mechanisms of NIS regulation with respect to cytokine modulation in thyroid autoimmune disease remain still unproven and data of experimental in vivo studies and clinical trials in patients with thyroid autoimmune disease have to further elucidate these open questions in the future.

Key words:

Thyroid autoimmune disease - NIS regulation - cytokines

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Prof. Dr. P.-M. Schumm-Draeger

Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main

Zentrum der Inneren Medizin

Medizinische Klinik I

Endokrinologie, Diabetes und Angiologie

Theodor-Stern-Kai 7

D-60590 Frankfurt/Main

Germany

Phone: + 49-69-6301-4231

Fax: +49-69-6301-7816

Email: Schumm-Draeger@em.uni-frankfurt.de

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