Planta Med 2000; 66(7): 644-647
DOI: 10.1055/s-2000-8624
Georg Thieme Verlag Stuttgart · New York

Inducible Nitric Oxide Synthase Inhibitors from Saposhnikovia divaricata and Panax quinquefolium

Chuen-Neu Wang1 , Young-Ji Shiao1 , Yueh-Hsiung Kuo2 , Chien-Chih Chen1 , Yun-Lian Lin1,*
  • 1 National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C.
  • 2 Department of Chemistry, National Taiwan University, Taipei, Taiwan, R.O.C.
Further Information

Publication History

Publication Date:
31 December 2000 (online)


A series of polyacetylenes, falcarinone, panaxynol, falcarindiol, panaxydol, and panaxytriol, were isolated from Saposhnikovia divaricata (Turcz.) Schischk and Panax quinquefolium L. These polyacetylenes were identified as active principles on the inhibition of nitrite production by inducible nitric oxide synthase (iNOS). Treatment with 10 μM of panaxynol, falcarindiol, panaxydol and panaxytriol decreased the LPS/IFN-γ-stimulated accumulation of nitrite by 71.92 ± 3.07, 69.95 ± 3.68, 45.48 ± 6.11 and 36.85 ± 8.80 %, respectively. The IC50 value of falcarinone, panaxynol, falcarindiol, panaxydol and panaxytriol was > 20, 2.23, 1.98, 6.58 and 9.85 μM, respectively.


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