Planta Med 2000; 66(6): 572-575
DOI: 10.1055/s-2000-8603
Georg Thieme Verlag Stuttgart · New York

Isoflavonoids from Pueraria mirifica and their Estrogenic Activity

Sunee Chansakaow1 , Tsutomu Ishikawa1,*, Keiko Sekine (née Yoshizawa)2 , Mineaki Okada2 , Yoshihiro Higuchi3 , Momoe Kudo3 , Chaiyo Chaichantipyuth4
  • 1 Faculty of Pharmaceutical Sciences, Chiba University, Inage, Chiba, Japan
  • 2 R & D Division, Nippon Kayaku Co. Ltd., Kita, Tokyo, Japan
  • 3 Central Research Laboratory, Shiratori Pharmaceutical Co. Ltd., Narashino, Chiba, Japan
  • 4 Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
Further Information

Publication History

Publication Date:
31 December 2000 (online)


Nine isoflavonoids including a new pterocarpene, puemiricarpene, were isolated from the tuberous root of Pueraria mirifica (Leguminosae). The structure of puemiricarpene was determined by spectroscopic means. Estrogenic activity of the isolated isoflavonoids was tested using MCF-7 human breast cancer cells. Moderate activity was observed for kwakhurin, a prenylated isoflavonoid.


Prof. Dr. Tsutomu Ishikawa

Faculty of Pharmaceutical Sciences Chiba University

1-33 Yayoi, Inage

Chiba 263-8522


Email: [email protected]

Phone: +81-43-290-2910