Anti-Platelet Aggregation Alkaloids and Lignans from Hernandia nymphaeifolia

Abstract

A new aporphine, N-(N-methylcarbamoyl)-O-methylbulbocapnine (1), together with seven known compounds, (-)-5′-methoxypodorhizol (2), a mixture of β-sitosterone (3) and stigmasta-4,22-dien-3-one (4), a mixture of 3β-hydroxystigmast-5-en-7-one (5) and 3β-hydroxystigmasta-5,22-dien-7-one (6), and a mixture of 6α-hydroxystigmast-4-en-3-one (7) and 6α-hydroxystigmasta-4,22-dien-3-one (8), were isolated in continuing studies on the trunk bark of Formosan Hernandia nymphaeifolia. The structures of these compounds were determined through spectral analyses. In addition, the previously reported six alkaloids, laurotetanine, oxohernagine, thalicarpine, reticuline, (+)-vateamine-2′-β-N-oxide, (+)-hernandaline and six lignans, (+)-epiaschantin, (+)-epimagnolin, (+)-epiyangambin, (-)-hernone, (-)-yatein, (-)-deoxypodophyllotoxin were demonstrated to have anti-platelet aggregation activity.

Key words

Hernandia nymphaeifolia - Hernandiaceae - bark - aporphine alkaloids - lignans - N-(N-methylcarbamoyl)-O-methylbulbocapnine - anti-platelet aggregation activity

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