Structure and Antiprotozoal Activity of Triterpenoid Saponins from Glinus oppositifolius
31 December 2000 (online)
Two new triterpenoid saponins, glinosides A and B, isolated from the aerial parts of Glinus oppositifolius, have been characterized by 1D, 2D, NMR and high-resolution mass spectral (HRMS) techniques. Their structures were established respectively as 16-O-(β-arabinopyranosyl)-3-oxo-12,16β,21β,22-tetrahydroxyhopane for glinoside A and 16-O-(β-arabinopyranosyl)-3-oxo-12,16β,22-trihydroxyhopane for glinoside B. Results presented evidence that fractions had a better antiplasmodial activity (IC50 = 31.80 μg/ml) than pure glinoside A (IC50 = 42.30 μg/ml).