Planta Med 2000; 66(4): 368-371
DOI: 10.1055/s-2000-8551
Georg Thieme Verlag Stuttgart · New York

Structure and Antiprotozoal Activity of Triterpenoid Saponins from Glinus oppositifolius

Fanta Traore1 , Robert Faure2 , Evelyne Ollivier1,*, Monique Gasquet3 , Nadine Azas3 , Laurent Debrauwer4 , Arouna Keita5 , Pierre Timon-David3 , Guy Balansard1
  • 1 Laboratoire de Pharmacognosie, Faculté de Pharmacie, Marseille, France
  • 2 ESA 6009, Université d'Aix Marseille III, Marseille, France
  • 3 Laboratoire de Parasitologie, Faculté de Pharmacie, Marseille, France
  • 4 INRA Centre de Recherche de Toulouse, Laboratoire des Xénobiotiques, Toulouse, France
  • 5 Département de Médecine Traditionelle, Bamako, Mali
Further Information

Publication History

Publication Date:
31 December 2000 (online)


Two new triterpenoid saponins, glinosides A and B, isolated from the aerial parts of Glinus oppositifolius, have been characterized by 1D, 2D, NMR and high-resolution mass spectral (HRMS) techniques. Their structures were established respectively as 16-O-(β-arabinopyranosyl)-3-oxo-12,16β,21β,22-tetrahydroxyhopane for glinoside A and 16-O-(β-arabinopyranosyl)-3-oxo-12,16β,22-trihydroxyhopane for glinoside B. Results presented evidence that fractions had a better antiplasmodial activity (IC50 = 31.80 μg/ml) than pure glinoside A (IC50 = 42.30 μg/ml).


  • 1 Gasquet  M,, Delmas  F,, Timond-David  P,, Keita  A,, Guindo  M,, Koita  N,, Diallo  D,, Doumbo  O.. Evaluation in vitro and in vivo of a traditional antimalarial drug: “Malarial 5”.  Fitoterapia. 1993;;  LXIV 423-6
  • 2 Barua  A K,, Banerjee  S K,, Das Gupta  C,, Basu  K,, Bose  L,, Chakrabarti  P.. The structure and stereochemistry of spergulagenol, a triterpene from Mollugo spergula.  Phytochemistry. 1980;;  19 1551-3
  • 3 Barua  A K,, Ray  S,, Datta  P K,, Venkateswaran  V.. A triterpene glycoside from Mollugo spergula.  Phytochemistry. 1986;;  25 1762-4
  • 4 Barua  A K,, Datta  P K,, Ray  S,, Venkateswaran  V,. Spergulacin-A: a triterpenoid saponin from Mollugo spergula.  Phytochemistry. 1986;;  25 2577-9
  • 5 Chakrabarti  P.. Studies on the constitution of spergulagenin-A, a novel triterpene from Mollugo spergula.  Indian Chemical Society. 1967;;  44 242-5
  • 6 Kitagawa  I,, Yamanaka  H,, Nakanishi  T,, Yosioka  I.. Spergulatriol, a new bisnor-triterpenoid sapogenol from the root of Mollugo spergula L.  Tetrahedron Letters. 1976;;  27 2327-30
  • 7 Hariharan  V,, Rangaswami  S.. Steroids and triterpenoids from the roots of Mollugo spergula.  Phytochemistry. 1971;;  10 621-4
  • 8 Kitagawa  I,, Susuki  H,, Kitazawa  K,, Yamao  N,, Yosioka  I.. Saponin and sapogenol (IX.1) Structure of spergulagenin-A, a new migrated hopane-type sapogenol from Mollugo spergula.  Chemical & Pharmaceutical Bulletin. 1975;;  23 355-6
  • 9 Doddrell  D,, Pegg  D T,, Bandall  M R.. Distortionless enhancement of NMR signals by polarization transfer.  Journal of Magnetic Resonance. 1982;;  48 323-7
  • 10 Hurd  R E,, John  B K.. Gradient enhanced spectroscopy.  Journal of Magnetic Resonance. 1990;;  87 422-8
  • 11 Hurd  R E,, John  B K.. Gradient enhanced proton-detected heteronuclear multiple-quantum coherence spectroscopy.  Journal of Magnetic Resonance. 1991;;  91 648-53
  • 12 Wilker  W,, Leibfritz  D,, Kerssebaum  R,, Bermel  W.. Gradient selection in inverse heteronuclear correlation spectroscopy.  Magnetic Resonance in Chemistry. 1993;;  31 287-92
  • 13 Hanoun  J P,, Morel  S,, Galy  J P,, Faure  R.. 1H and 13C chemical shifts of some tetracyclic and pentacyclic acridinone derivatives.  Magnetic Resonance in Chemistry. 1999;;  37 86-9
  • 14 Trager  W,, Polonsky  J.. Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro. .  American Jorunal of Tropical medicine and Hygienics. 1981;;  56 531-7

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