Planta Med 2000; 66(4): 368-371
DOI: 10.1055/s-2000-8551
Letter
Georg Thieme Verlag Stuttgart · New York

Structure and Antiprotozoal Activity of Triterpenoid Saponins from Glinus oppositifolius

Fanta Traore1 , Robert Faure2 , Evelyne Ollivier1,*, Monique Gasquet3 , Nadine Azas3 , Laurent Debrauwer4 , Arouna Keita5 , Pierre Timon-David3 , Guy Balansard1
  • 1 Laboratoire de Pharmacognosie, Faculté de Pharmacie, Marseille, France
  • 2 ESA 6009, Université d'Aix Marseille III, Marseille, France
  • 3 Laboratoire de Parasitologie, Faculté de Pharmacie, Marseille, France
  • 4 INRA Centre de Recherche de Toulouse, Laboratoire des Xénobiotiques, Toulouse, France
  • 5 Département de Médecine Traditionelle, Bamako, Mali
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

Two new triterpenoid saponins, glinosides A and B, isolated from the aerial parts of Glinus oppositifolius, have been characterized by 1D, 2D, NMR and high-resolution mass spectral (HRMS) techniques. Their structures were established respectively as 16-O-(β-arabinopyranosyl)-3-oxo-12,16β,21β,22-tetrahydroxyhopane for glinoside A and 16-O-(β-arabinopyranosyl)-3-oxo-12,16β,22-trihydroxyhopane for glinoside B. Results presented evidence that fractions had a better antiplasmodial activity (IC50 = 31.80 μg/ml) than pure glinoside A (IC50 = 42.30 μg/ml).