Rofo 2000; 172(10): 798-801
DOI: 10.1055/s-2000-7903
© Georg Thieme Verlag Stuttgart · New York

MRI Evaluation of Aseptic Osteonecrosis in Children over the Course of Hyperbaric Oxygen Therapy

A. Scherer1 V. Engelbrecht1 B. Bernbeck2 P. May1 R. Willers3 U. Göbel2 U. Mödder1
  • 1Institute of Diagnostic Radiology, Heinrich-Heine University, Düsseldorf
  • 2Department of Pediatric Hematology and Oncology, Heinrich-Heine University, Düsseldorf
  • 3Institute of Statistics, Heinrich-Heine University, Düsseldorf
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Purpose: The study aimed at MRI evaluation of aseptic osteonecrosis (AON) in children over the course of hyperbaric oxygen (HBO) therapy. Material and Methods: Retrospective analysis of 72 MRI studies in 20 children presenting with AON during chemotherapy. Two groups were differentiated: Gr. I (n = 8) was treated exclusively with relief of weightbearing structures, Gr. II (n = 12) was additionally treated with HBO therapy. The MRI examinations were evaluated by a point-score system (1 - 6 points) by two radiologists. Results: Gr. II initially showed more severe findings (average score: 3.4) in comparison to Gr. I (average score: 2.65). During the follow-up time period the average scores rose to 3.2 score-points in Gr. I and 4.1 points in Gr. II. No statistically significant difference was evident between the two groups in the course of AON. Conclusion: The majority of chemotherapy associated AON which initially present with advanced findings show a progression in MRI over their further course. HBO therapy in addition to the relief of affected weightbearing structures statistically shows no significant improvement in MRI morphology during the course of the treatment.


Axel Scherer, , MD 

Institute of Diagnostic Radiology Heinrich-Heine University

Moorenstr. 5

40225 Düsseldorf

Phone: + 49- 211- 8 117 752

Fax: + 49- 211- 8 116 299