Diagnostic Quality in Endoscopic Retrograde Cholangiopancreatography: Comparison Between Iodixanol and Iopromide

D. F. Martin; R. E. England; T. Rösch; E. Biehl; B. Jeschke; N. Fritz; D. Heldwein; A. Klauser; A. Klaveness; D. Kristoffersen

doi:10.1055/s-2000-7707

Endoscopy 2000; 32(10): 783-787
DOI: 10.1055/s-2000-7707

Original Article

Diagnostic Quality in Endoscopic Retrograde Cholangiopancreatography: Comparison Between Iodixanol and Iopromide

D. F. Martin ¹ , R. E. England ¹ , T. Rösch ² , E. Biehl ² , B. Jeschke ² , N. Fritz ² , D. Heldwein ³ , A. Klauser ³ , A. Klaveness ⁴ , D. Kristoffersen ⁴

¹ Dept. of Radiology, South Manchester University Hospitals, Withington Hospital, Manchester, UK
² Dept. of Internal Medicine II, Technical University of Munich, Munich, Germany
³ MCHE Klinik, K Innenstadt, Ludwig-Maximilians University, Munich, Germany
⁴ Nycomed Imaging AS, Oslo, Norway

Abstract

Background and Study Aims: The contrast medium for endoscopic retrograde cholangiopancreatography (ERCP) must produce adequate images, whilst keeping the risk of complications to a minimum. There is a theoretical reason to suppose that a dimeric isosmolar medium may be superior to a monomeric hyperosmolar medium. We have compared two such media in a triple-centre double-blind randomized study on patients referred with a clinical indication for ERCP.

Patients and Methods: A total of 160 patients were randomly allocated to either Iodixanol or Iopromide. Assessments were made of the quality of images and the complications encountered.

Results: A total of 151 patients were evaluated. Apart from a trend towards better diagnostic quality for main pancreatic duct imaging with Iodixanol, there were no differences between the two groups. The overall frequencies of adverse events were similar.

Conclusions: Iodixanol is a safe and effective water-soluble contrast medium for ERCP, comparable to Iopromide, but despite theoretical advantages Iodixanol has no clear practical benefit.

Full Text

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D. F. Martin,M.D., F.R.C.R., F.R.C.P.

Dept. of Radiology South Manchester University Hospitals Withington Hospital

Manchester M20 2LR United Kingdom

Fax: Fax:+ 44-161-4481688

Email: E-mail:derrickmartin@hotmail.com