Zusammenfassung
Das villoglanduläre Karzinom der Zervix wurde erstmals 1989 von Young und Scully als
eigene Entität beschrieben. Bei dem vorliegenden Fall war bei einer 45-jährigen Patientin
im Rahmen der Krebsvorsorgeuntersuchung ein villöser Umbau der gesamten Zervix aufgefallen,
während die zytologische Untersuchung zunächst unauffällig war. Die Diagnose wurde
durch Kolposkopie und Biopsie gestellt. Die Therapie bestand in einer Konisation und
modifiziert radikalen Hysterektomie mit pelviner Lymphonodektomie. In der Literatur
sind bisher nur 71 weitere Fälle beschrieben. Diese zeichneten sich durch eine günstige
Prognose aus, sofern keine plattenepithelialen oder drüsigen Zweitkarzinome bestanden.
Ist ein Zweitkarzinom durch Konisation ausgeschlossen und besteht Kinderwunsch, kann
die Gebärmutter erhalten werden. In allen anderen Fällen sollte eine Hysterektomie
erfolgen.
Abstract
Villoglandular carcinoma of the cervix was first described in 1989 by Young and Scully.
The case of a 45-year-old patient is presented. She was without symptoms, and cytological
screening did not reveal any abnormality. Diagnosis was made through colposcopic biopsy.
Cone biopsy with subsequent modified radical hysterectomy and pelvic lymph node dissection
was performed. A review of the literature revealed 71 cases of villoglandular carcinoma
of the cervix. These appear to have a favorable prognosis, as long as coexisting squamous
carcinoma or adenocarcinoma of the cervix have been excluded by cone biopsy. In these
women, cone biopsy as the sole method of treatment may be considered to preserve fertility.
In all other cases, hysterectomy should be performed.
Schlüsselwörter
Villoglanduläres Karzinom - Zervix - Zweitkarzinome
Key words
Villoglandular carcinoma - Cervix - Coexisting carcinomas
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Univ.-Prof. Dr. med. Ralph J. Lellé
Frauenklinik der Westfälischen Wilhelms-Universität
Albert-Schweitzer-Straße 33
48149 Münster
eMail: E-mail: rlelle@gmx.net
